How to Use Grape Seed Extract

Co-authored by Patricia Somers, RD, PhD and Jessica Gibson

Last Updated: November 2, 2021 References

Grape seed extract has gotten a lot of interest recently. Although more scientific studies are needed to determine its exact health benefits, early research indicates that grape seed extract may be a helpful addition to your diet. ^{[1]
X
Trustworthy Source
PubMed Central
Journal archive from the U.S. National Institutes of Health
Go to source} Learn the basics about adding the supplement and consider using it to treat a specific condition or health concern.

Method 1

Method 1 of 2:

Taking Grape Seed Extract

1
Purchase grape seed extract. Grape seed extract is a byproduct of wine making, and can be sold in liquid form and dried form. If you buy the dried extract, you can look for capsules or tablets. Regardless of what you choose, look for an extract that contains at least 40% of proanthocyanidins.
- Most standard doses of grape seed extract contain between 50 and 100 mg of the extract.
2
Talk with your doctor. You should always talk with your doctor before taking any new supplements, especially if you're taking other vitamins, supplements, or medications. Talk with your doctor about taking grape seed extract if you have a bleeding disorder. Avoid taking it if you're allergic to grapes since you'll also be allergic to the extract.^{[2]
X
Research source}
- Children, pregnant women and nursing women shouldn't take grape seed extract.
Advertisement
3
Watch for side effects of using grape seed extract. Most people don't experience side effects when supplementing with grape seed extract. But if you do have side effects, cut back on your grape seed extract dosage until you no longer experience side effects. Watch for these side effects:^{[3]
X
Research source}
- Headache
- Itchy scalp
- Nausea
- Hives
- Indigestion
- Dizziness
4
Avoid taking grape seed extract with vitamin C. If you're taking medication to treat hypertension (high blood pressure) or you're just concerned about keeping your blood pressure low, avoid taking grape seed extract along with vitamin C. Research has shown that combining these supplements increases blood pressure.^{[4]
X
Trustworthy Source
PubMed Central
Journal archive from the U.S. National Institutes of Health
Go to source}
- If you're on high blood pressure medication, you should also talk to your doctor about foods that are high in polyphenols (like cocoa, dark chocolate, and flaxseed). Conflicting research states polyphenols may help lower your blood pressure, so consulting your doctor about a polyphenol-rich diet is advisable.^{[5]
  X
  Research source}

Method 2

Method 2 of 2:

Using Grape Seed Extract for Specific Health Concerns

1
Kick start weight loss. If you've gained weight because of a high-fat diet, grape seed extract can reduce your weight gain and other negative health effects that are associated with obesity. To get these benefits, take a standard daily dose of 250 mg of grape seed extract.^{[6]
X
Trustworthy Source
PubMed Central
Journal archive from the U.S. National Institutes of Health
Go to source}
- Grape seed extract reduces health problems associated with obesity, like heart disease, insulin resistance, and hyperlipidemia (high levels of lipids in the blood).
2
Lower your blood pressure with grape seed extract. Long range studies of grape seed extract and blood pressure indicates that grape seed extract is effective at lowering systolic blood pressure. It can also significantly lower your heart rate. To get these benefits, take the standard recommended dose of between 150 and 300 mg of grape seed extract a day.^{[7]
X
Trustworthy Source
PubMed Central
Journal archive from the U.S. National Institutes of Health
Go to source}
- The same study didn't find any reduction of lipid or cholesterol levels.
3
Reduce your risk for cancer. Although more studies are needed, early research shows that taking grape seed extract can reduce your risk for skin, colorectal, prostrate, breast and lung cancers.^{[8]
X
Trustworthy Source
PubMed Central
Journal archive from the U.S. National Institutes of Health
Go to source} The study was based on a daily dosage of between 100 and 500 mg of grape seed extract taken every day.
- You can also get similar anti-cancer benefits by eating a healthy diet that includes grapes.
4
Reduce leg swelling. If you've injured your legs or have had surgery, grape seed extract may be able to reduce the swelling. This is because it may heal the veins in your leg so they can return to their normal size. Grape seed extract may be effective in speeding healing time.^{[9]
X
Research source} To take grape seed extract for swelling, take 150 to 300 mg a day.
- Grape seed extract is often used to treat hemorrhoids or swollen legs caused by problems with veins.