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DNA Structure and Function
DNA Repair
Biology Textbooks Boundless Biology DNA Structure and Function DNA Repair
Biology Textbooks Boundless Biology DNA Structure and Function
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DNA Repair

DNA Ligase I Repairing Chromosomal Damage

DNA Ligase I Repairing Chromosomal Damage

DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. A special enzyme, DNA ligase (shown here in color), encircles the double helix to repair a broken strand of DNA. DNA ligase is responsible for repairing the millions of DNA breaks generated during the normal course of a cell's life. Without molecules that can mend such breaks, cells can malfunction, die, or become cancerous. DNA ligases catalyse the crucial step of joining breaks in duplex DNA during DNA repair, replication and recombination, and require either Adenosine triphosphate (ATP) or Nicotinamide adenine dinucleotide (NAD+) as a cofactor.

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Related Terms

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