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Registry of Toxic Effects of Chemical Substances (RTECS)

Uracil, 5-bromo-3-sec-butyl-6-methyl-

RTECS #

YQ9100000

CAS #

314-40-9; 154670-12-9

Updated

September 201

Molecular Weight

261.15

Molecular Formula

C9H13BrN2O2

Synonyms

(+-)-Bromacil
3-sek.Butyl-5-brom-6-methyluracil (German)
5-Bromo-3-sec-butyl-6-methyluracil
5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
5-Bromo-6-methyl-3-(1-methylpropyl)uracil
Borea
Bromacil
Bromacil (ACGIH)
Bromax
Bromazil
Cynogan
Du Pont herbicide 976
Eerex Granular Weed Killer
Eerex Water Soluble Concentrate Weed Killer
Herbicide 976
Hyvar X
Hyvar X bromacil
Hyvar X Weed Killer
Hyvar X-L
Hyvar X-WS
Hyvarex
Krovar II
Nalkil
Urox B
Urox B water soluble concentrate weed killer
Urox HX granular weed killer
Urox-HX

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslymphocyte/mouse750 mg/LNTIS** PB84-138973
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2000 ppmJPFCD2 15,867,1980
sex chromosome loss and nondisjunction/Neurospora crassa10 mg/LMUREAV 167,35,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 38 mg/m3/2H (7-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		NTIS** PB277-077

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >4800 mg/m3PEMNDP 9,93,1991
oral/Dog Lethal dose: >5 gm/kgTXAPA9 34,189,1975
oral/mouse lethal dose (50 percent kill): 3040 mg/kgJPFCD2 15,867,1980
oral/rat lethal dose (50 percent kill): 641 mg/kgFAATDF 7,299,1986
skin/rabbit lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,93,1991
skin/rat lethal dose (50 percent kill): >2500 mg/kgFAATDF 7,299,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 10350 mg/kg/2W- intermittentBehavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 34,189,1975
oral/rat lowest published toxic dose: 45625 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 34,189,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,92,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (11 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (11 mg/m3), short term exposure limit 3 ppm (33 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (10 mg/m3);short term exposure limit 2 ppm (20 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (11 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (10 mg/m3), inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (11 mg/m3);short term exposure limit 2 ppm (22 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMACIL-air10H time-weighted average 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80830; Number of Industries 7; Total Number of Facilities 755; Number of Occupations 6; Total Number of Employees Exposed 4372; Total Number of Female Employees Exposed 63
National Occupational Hazard Survey 1974Hazard Code 80830; Number of Industries 11; Total Number of Facilities 362; Number of Occupations 5; Total Number of Employees Exposed 1905

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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