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Registry of Toxic Effects of Chemical Substances (RTECS)

Picolinic acid, 4-amino-3,5,6-trichloro-

RTECS #

TJ7525000

CAS #

1918-02-1

Updated

September 201

Molecular Weight

241.46

Molecular Formula

C6H3Cl3N2O2

Synonyms

2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
3,5,6-Trichloro-4-aminopicolinic acid
4-Amino-3,5,6-trichloro-2-picolinic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichlorpicolinsaeure (German)
Amdon
Amdon grazon
ATCP
Borolin
Grazon
K-Pin
NCI-C00237
Picloram
Picloram (ACGIH:OSHA)
Picloram, acid
Tordon

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Other microorganisms200 µg/plate (-enzymatic activation step)MUREAV 57,277,1978
mutation in microorganisms/Saccharomyes cerevisiae100 mg/L (-enzymatic activation step)TGANAK 18,455,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFCTXAV 10,797,1972
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemFCTXAV 10,797,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 340 gm/kg/80W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors		JTEHD6 7,207,1981
oral/rat toxic dose: 208 gm/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		NCITR* NCI-TR-23,1978
oral/rat toxic dose: 416 gm/kg/80W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Endocrine: Tumors		NCITR* NCI-TR-23,1978
oral/rat toxic dose: 417 gm/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors		JTEHD6 7,207,1981
oral/rat lowest published toxic dose: 208 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors		JTEHD6 7,207,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/duck lethal dose (50 percent kill): >2 gm/kgDOEAAH 35,25,1979
oral/rabbit lethal dose (50 percent kill): 2 gm/kgGUCHAZ 6,414,1973
oral/rat lethal dose (50 percent kill): 4012 mg/kgFEREAC 64,420,1999
skin/rabbit lethal dose (50 percent kill): >4 gm/kgWRPCA2 9,119,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight		AECTCV 24,449,1993
oral/rat lowest published toxic dose: 7 gm/kg/2W- continuousLiver: Changes in liver weightJTEHD6 20,367,1987
oral/rat lowest published toxic dose: 27300 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight		JTEHD6 20,367,1987
oral/rat lowest published toxic dose: 10920 mg/kg/26W- continuousLiver: Changes in liver weightJTEHD6 20,367,1987
oral/rat lowest published toxic dose: 73 gm/kg/1Y- continuousLiver: Changes in liver weightJTEHD6 20,367,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,481,1991
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,436,2005
TOXICOLOGY REVIEWFEREAC 72,41913,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,143,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83786; Number of Industries 1; Total Number of Facilities 45; Number of Occupations 2; Total Number of Employees Exposed 314
National Occupational Hazard Survey 1974Hazard Code 83786; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:ratNCITR* NCI-TR-23,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouseNCITR* NCI-TR-23,1978
On EPA IRIS database

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