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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Oxathiolane 2,2-dioxide

RTECS #

RP5425000

CAS #

1120-71-4

Updated

September 201

Molecular Weight

122.15

Molecular Formula

C3H6O3S

Synonyms

1,3-Propane sultone
1-Propanesulfonic acid-3-hydroxy-gamma-sultone
3-Hydroxy-1-propanesulfonic acid gamma-sultone
3-Hydroxy-1-propanesulphonic acid sultone
gamma-Propane sultone
Propane sultone
Propane sultone (ACGIH)
Propanesultone
RCRA waste number U193

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mild34ZIAG -,498,1969

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mmol/LTOLED5 28,139,1985
Cytogenetic Analysisfibroblast/hamster125 mg/L/24HMUREAV 48,337,1977
Cytogenetic Analysislung/hamster10 mg/LATSUDG 4,41,1980
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA Damage/Bacillus subtilis50 nmol/LCNREA8 41,4368,1981
DNA Damagefibroblast/human5 mg/LCBINA8 22,185,1978
DNA Damagemammary gland/human10 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damageintraperitoneal/mouse200 mg/kgMUREAV 467,83,2000
DNA Damageintravenous/rat31 mg/kgTCMUD8 7,175,1987
DNA inhibitionskin/mouse2 mmol/kgCNREA8 33,769,1973
DNA inhibitionoral/mouse20 gm/kgARGEAR 51,605,1981
DNA repair/Other microorganisms610 µg/plateBIZNAT 95,463,1976
DNA repair/Escherichia coli500 µg/discJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae1000 ppmJJIND8 62,901,1979
host-mediated assaySalmonella typhimurium/mouse12 mg/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/mouse18 mg/kg/48H- intermittentMUREAV 389,3,1997
morphological transformfibroblast/mouse30 µg/LCRNGDP 3,377,1982
morphological transformembryo/mouse50 mg/LTOLED5 9,301,1981
morphological transformintraperitoneal/hamster1 gm/kgARPAAQ 95,380,1973
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/hamster1 mg/LIJCNAW 19,642,1977
morphological transformembryo/rat5 mg/LJNCIAM 51,799,1973
morphological transformother cell types/human7500 µg/LCNREA8 41,5096,1981
mutation in mammalian somatic cellsfibroblast/human30 mg/LCNREA8 41,1620,1981
mutation in microorganisms/Schizosaccharomyces pombe7900 µmol/L (-enzymatic activation step)CBINA8 14,195,1976
mutation in microorganisms/Escherichia coli1 gm/L (-enzymatic activation step)ATXKA8 28,93,1971
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+enzymatic activation step)JJIND8 62,893,1979
mutation in microorganisms/Salmonella typhimurium70 µg/plate (-enzymatic activation step)PNASA6 72,5135,1975
mutation in microorganisms/Serratia marcescens25 mg/L (-enzymatic activation step)ATXKA8 30,67,1972
mutation in microorganisms/Other microorganisms1600 mg/L (-enzymatic activation step)MOPMA3 6,667,1970
other mutation test systems/Bacillus subtilis50 mmol/LJOBAAY 136,854,1978
other mutation test systems/Salmonella typhimurium16 mg/LMUREAV 192,239,1987
sister chromatid exchangelymphocyte/human500 µmol/LTOLED5 28,139,1985
specific locus testoral/rat420 mg/kg/14D- intermittentMUREAV 721,163,2011
Unscheduled DNA Synthesisskin/mouse2 mmol/kgCNREA8 33,769,1973
Unscheduled DNA Synthesisfibroblast/human200 µmol/L/2H33AQAA -,103,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/rat 80 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathIARCCD 4,45,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intravenous/rat lowest published toxic dose: 20 mg/kg (15D pregnant)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Brain and Coverings: Tumors		IARCCD 4,45,1973
oral/rat lowest published toxic dose: 7840 mg/kg/60W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors		NATUAS 230,460,1971
oral/rat toxic dose: 1100 mg/kg/37W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Peripheral Nerve and Sensation: Peripheral nerve tumors		ZEKBAI 75,69,1970
oral/rat toxic dose: 12 gm/kg/60W- continuousTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors		JJIND8 67,75,1981
oral/rat toxic dose: 13 gm/kg/32W- continuousTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors		JJIND8 67,75,1981
skin/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease		TXCYAC 6,139,1976
skin/mouse toxic dose: 50 mg/kg/1W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		TXAPA9 37,93,1976
subcutaneous/mouse lowest published toxic dose: 756 mg/kg/63W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		JNCIAM 46,143,1971
subcutaneous/rat lowest published toxic dose: 10 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		ZEKBAI 75,69,1970
subcutaneous/rat toxic dose: 166 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		INTSAO 66,161,1981
subcutaneous/rat toxic dose: 559 mg/kg/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		INTSAO 66,161,1981
subcutaneous/rat toxic dose: 434 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		INTSAO 66,161,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 2140 mg/m3/6HEye: Lacrimation

Vascular: Regional or general arteriolar or venous dilation

Skin and Appendages: Other: Hair		NTIS** OTS0555330
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair		NTIS** OTS0555330
intraperitoneal/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea		NTIS** OTS0555330
oral/mouse lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair		NTIS** OTS0555330
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea		NTIS** OTS0555330
skin/mouse lowest published lethal dose: 1000 gm/kgTXCYAC 6,139,1976
subcutaneous/rat lethal dose (50 percent kill): 135 mg/kgZEKBAI 75,69,1970

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possible (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1095,1999
TOXICOLOGY REVIEWTOLED5 151,251,2004
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPANE SULTONE-airCarcinogen lowest feasible concentrationNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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