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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, triiodo-

RTECS #

PB7000000

CAS #

75-47-8

Updated

September 201

Molecular Weight

393.72

Molecular Formula

CHI3

Synonyms

Carbon triiodide
Dezinfekt V
Iodoform
Iodoform (ACGIH)
Jodoform (Czech)
NCI-C04568
Triiodomethane
Trijodmethane (Czech)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/human100 µmol/L/3HMUREAV 649,45,2008
morphological transformembryo/hamster10 mg/LSHIGAZ 74,1385,1987
mutation in microorganisms/Salmonella typhimurium67 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
sister chromatid exchangeembryo/hamster1 mg/LSHIGAZ 74,1385,1987
Unscheduled DNA Synthesisembryo/hamster1 mg/LSHIGAZ 74,1385,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 165 ppm/7HLung, Thorax, or Respiration: Respiratory stimulationJTEHD6 8,59,1981
inhalation/rat lethal concentration (50 percent kill): 183 ppm/7HVCVGH* -,605,1990
oral/Dog lowest published lethal dose: 10 gm/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea		ZEPTAT 1,446,1905
oral/guinea pig lethal dose (50 percent kill): 487 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		ZDTUAB 27(5),9,1983
oral/mammal (species unspecified) lowest published lethal dose: 1 gm/kgHBAMAK 4,1289,1935
oral/mouse lethal dose (50 percent kill): 470 mg/kgGISAAA 52(11),74,1987
oral/rabbit lethal dose (50 percent kill): 450 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		ZDTUAB 27(5),9,1983
oral/rat lethal dose (50 percent kill): 355 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		ZDTUAB 27(5),9,1983
skin/rat lethal dose (50 percent kill): 1184 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		ZDTUAB 27(5),9,1983
subcutaneous/mammal (species unspecified) lowest published lethal dose: 1500 mg/kgHBAMAK 4,1289,1935
subcutaneous/mouse lethal dose (50 percent kill): 630 mg/kgBehavioral: Antipsychotic

Vascular: Other changes

Lung, Thorax, or Respiration: Other changes		TXAPA9 4,354,1962
subcutaneous/rabbit lowest published lethal dose: 500 mg/kgZEPTAT 1,446,1905
unreported route/frog lowest published lethal dose: 606 mg/kgZEPTAT 1,446,1905

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 875 mg/kg/35D- intermittentLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		GISAAA 52(11),74,1987
oral/rat lowest published toxic dose: 2166 mg/kg/61D- intermittentLiver: Other changesZDTUAB 27(5),9,1983

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.6 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWMUREAV 705,184,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.6 ppm (10 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 ppm (3 mg/m3);KZW 0.4 ppm (6 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.6 ppm (10 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 ppm (3 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 ppm (3.3 mg/m3), short term exposure limit 0.6 ppm (9.8 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.6 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 ppm (3 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.6 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.6 ppm (10 mg/m3);short term exposure limit 1 ppm (20 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.6 ppm (10 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.2 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,6 ppm (9,7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.6 ppm (10 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.8 ppm (9.8 mg/m3);short term exposure limit 1 ppm (16 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODOFORM-air10H time-weighted average 0.6 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84474; Number of Industries 4; Total Number of Facilities 510; Number of Occupations 12; Total Number of Employees Exposed 22584; Total Number of Female Employees Exposed 20381
National Occupational Hazard Survey 1974Hazard Code 84474; Number of Industries 2; Total Number of Facilities 390; Number of Occupations 5; Total Number of Employees Exposed 1882

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,ratNCITR* NCI-TR-110,1978

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