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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, 2,2,2-trifluoroethyl vinyl

RTECS #

KO4250000

CAS #

406-90-6

Updated

April 2012

Molecular Weight

126.09

Molecular Formula

C4H5F3O

Synonyms

2,2,2-Trifluoroethyl vinyl ether
Ethene, (2,2,2-trifluoroethoxy)-
Floroxene
Fluooxene
Fluoromar
Fluoroxene
Fluorxene
Fluroxene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium5 pph (-enzymatic activation step)MUREAV 58,183,1978
mutation in microorganisms/Escherichia coli5 pph (+enzymatic activation step)MUREAV 58,183,1978
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster2 pph/1HANESAV 62,305,1985
sister chromatid exchangeovary/hamster24700 ppmANESAV 50,426,1979

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/monkey 8 pph/20M (22W pregnant)Reproductive: Other effects to embryo or fetusAANEAB 20,183,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/man lowest published toxic concentration: 2 pph/90MLiver: Jaundice, other or unclassified

Liver: Liver function tests impaired		ANESAV 37,462,1972
inhalation/mouse Lowest published lethal concentration: 4 pph/1HBJANAD 48,399,1976
intraperitoneal/rat lethal dose (50 percent kill): 5600 mg/kgTXAPA9 71,84,1983

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMSUDL 7,93,1987
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (10 mg/m3);KZW 4 ppm (20 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (10 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (10 mg/m3), NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUROXENE-airceiling concentration 2 ppm/60MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M5153; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 5
National Occupational Hazard Survey 1974Hazard Code M5153; Number of Industries 1; Total Number of Facilities 112; Number of Occupations 3; Total Number of Employees Exposed 448

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY

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