Registry of Toxic Effects of Chemical Substances (RTECS)
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Benzene, divinyl-
RTECS #
CZ9370000CAS #
1321-74-0Updated
September 201Molecular Weight
130.20Molecular Formula
C10H10Synonyms
Benzene, diethenyl- (9CI)Diethenylbenzene
Divinyl benzene
Divinyl benzene (ACGIH)
Divinylbenzene
Vinylstyrene
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/mouse | 53 ppm/6H/3D-continuous | MUREAV 370,107,1996 |
| micronucleus test | inhalation/mouse | 53 ppm/6H/3D-continuous | MUREAV 370,107,1996 |
| sister chromatid exchange | inhalation/mouse | 53 ppm/6H/3D-continuous | MUREAV 370,107,1996 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published lethal dose: 10 mL/kg | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | AMIHAB 19,403,1959 |
| oral/rat | lethal dose (50 percent kill): 5 mL/kg | VCVGH* -,189,1990 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | : 200 ppm/6H/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 100 ppm/6H/17D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 25 ppm/6H/17D- intermittent | Olfaction: Other olfaction effects Endocrine: Changes in thymus weight | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 25 ppm/6H/17D- intermittent | Olfaction: Other olfaction effects Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 200 ppm/6H/17D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Multiple effects Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 200 ppm/6H/14W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 25 ppm/6H/14W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 100 ppm/6H/14W- intermittent | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 100 ppm/6H/105W- intermittent | Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 30 ppm/6H/105W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 10 ppm/6H/105W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma | NTPTR* NTP-TR-534 |
| inhalation/mouse | : 10 ppm/6H/105W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes | NTPTR* NTP-TR-534 |
| inhalation/rat | : 400 ppm/6H/16D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/rat | : 50 ppm/6H/16D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight | NTPTR* NTP-TR-534 |
| inhalation/rat | : 200 ppm/6H/16D- intermittent | Liver: Changes in liver weight | NTPTR* NTP-TR-534 |
| inhalation/rat | : 100 ppm/6H/16D- intermittent | Olfaction: Other olfaction effects Eye: Other eye effects | NTPTR* NTP-TR-534 |
| inhalation/rat | : 400 ppm/6H/105W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-534 |
| inhalation/rat | : 400 ppm/6H/53W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-534 |
| inhalation/rat | : 400 ppm/6H/105W- intermittent | Kidney, Ureter, and Bladder: Other changes Kidney, Ureter, and Bladder: Kidney tumors Skin and Appendages: Tumors | NTPTR* NTP-TR-534 |
| inhalation/rat | : 400 ppm/6H/105W- intermittent | Lung, Thorax, or Respiration: Other changes | NTPTR* NTP-TR-534 |
| inhalation/rat | : 200 ppm/6H/105W- intermittent | Kidney, Ureter, and Bladder: Kidney tumors | NTPTR* NTP-TR-534 |
| inhalation/rat | : 100 ppm/6H/105W- intermittent | Brain and Coverings: Tumors | NTPTR* NTP-TR-534 |
| inhalation/rat | : 100 ppm/6H/105W- intermittent | Olfaction: Other olfaction effects | NTPTR* NTP-TR-534 |
| inhalation/rat | : 50 ppm/6H/14W- intermittent | Olfaction: Other olfaction effects Eye: Other eye effects | NTPTR* NTP-TR-534 |
| inhalation/rat | : 25 ppm/6H/14W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | NTPTR* NTP-TR-534 |
| inhalation/rat | : 200 ppm/6H/14W- intermittent | Cardiac: Changes in heart weight Related to Chronic Data: Changes in testicular weight | NTPTR* NTP-TR-534 |
| inhalation/rat | : 100 ppm/6H/14W- intermittent | Olfaction: Other olfaction effects | NTPTR* NTP-TR-534 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIVINYL BENZENE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 83286; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 11 | |
| National Occupational Hazard Survey 1974 | Hazard Code 83286; Number of Industries 5; Total Number of Facilities 164; Number of Occupations 14; Total Number of Employees Exposed 12271 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NTP Carcinogenesis studies; on test (two year studies), October 2000 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division