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Registry of Toxic Effects of Chemical Substances (RTECS)

Barium chloride

RTECS #

CQ8750000

CAS #

10361-37-2

Updated

September 201

Molecular Weight

208.24

Molecular Formula

BaCl2

Synonyms

Barium dichloride
NCI-C61074
SBA 0108E

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae14 mmol/LMUTAEX 1,21,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 16659 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Guinea pig, myocard Inhibitor Concentration Low: 1 mmol/L/30MCardiac: Pulse rate increased without fall in BPTIVIEQ 2,49,1988
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 2.1 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration Low: 0.03 µmol/LGastrointestinal: Contraction (isolated tissue)FTRPAE 83,1286,2012
In Vitro/Rat, kidney Inhibitor Concentration Low: 300 µmol/LIn Vitro Toxicity Studies: Membrane currentsTXCYAC 271,45,2010
intracerebral/mouse lethal dose (50 percent kill): 2.4 mg/kgHBTME* -,407,2007
intraperitoneal/mouse lethal dose (50 percent kill): 56.2 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany		VCVN1* -,136,1988
intraperitoneal/mouse lethal dose (50 percent kill): 39 mg/kgFATOBP 10,107,1975
intraperitoneal/rat lethal dose (50 percent kill): 24 mg/kgHBTME* -,407,2007
intravenous/cat lowest published lethal dose: 40 mg/kgEQSSDX 1,1,1975
intravenous/mouse lethal dose (50 percent kill): 12 mg/kgTXAPA9 22,150,1972
intravenous/rabbit lowest published lethal dose: 15 mg/kgEQSSDX 1,1,1975
intravenous/rabbit lowest published toxic dose: 4 mg/kgCardiac: Arrythmias (indlucing changes in conduction)FATOAO 51,50,1988
intravenous/rat lowest published lethal dose: 20 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Other changes		JLCMAK 15,35,1929
oral/Dog lowest published lethal dose: 90 mg/kgHBTME* -,407,2007
oral/guinea pig lethal dose (50 percent kill): 76 mg/kgFOREAE 7,313,1942
oral/horse, donkey lowest published lethal dose: 800 mg/kgHBTME* -,407,2007
oral/mammal (species unspecified) lethal dose (50 percent kill): 398 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting		GTPZAB 28(6),45,1984
oral/mouse lethal dose (50 percent kill): 150 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany		VCVN1* -,136,1988
oral/mouse lowest published lethal dose: 70 mg/kgEQSSDX 1,1,1975
oral/rabbit lowest published lethal dose: 170 mg/kgHBTME* -,407,2007
oral/rat lowest published lethal dose: 300 mg/kgHBTME* -,407,2007
oral/rat lethal dose (50 percent kill): 397 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany		VCVN1* -,136,1988
oral/rat lethal dose (50 percent kill): 118 mg/kgFOREAE 7,313,1942
parenteral/domestic animal lowest published lethal dose: 7 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness		NEZTAF 47,150,1999
parenteral/rabbit lowest published lethal dose: 20 mg/kgGastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased		MELAAD 30,44,1939
parenteral/rat lowest published toxic dose: 35 µg/kgCardiac: Arrythmias (indlucing changes in conduction)PCJOAU 37,6,2003
subcutaneous/cat lowest published lethal dose: 18 mg/kgEQSSDX 1,1,1975
subcutaneous/Dog lowest published lethal dose: 10 mg/kgEQSSDX 1,1,1975
subcutaneous/frog lowest published lethal dose: 910 mg/kgHBAMAK 4,1289,1935
subcutaneous/guinea pig lowest published lethal dose: 55 mg/kg27ZIAQ -,53,1973
subcutaneous/mouse lowest published lethal dose: 10 mg/kgNTIS** AEC-TR-6710
subcutaneous/rabbit lowest published lethal dose: 40 mg/kgEQSSDX 1,1,1975
subcutaneous/rat lethal dose (50 percent kill): 178 mg/kg27ZIAQ -,53,1973
unreported route/Dog lethal dose (50 percent kill): 90 mg/kgNEZTAF 47,150,1999
unreported route/horse, donkey lethal dose (50 percent kill): 800 mg/kgNEZTAF 47,150,1999
unreported route/human lowest published lethal dose: 114.3 mg/kgVCVN1* -,138,1988
unreported route/mouse lethal dose (50 percent kill): 7 mg/kgNEZTAF 47,150,1999
unreported route/rabbit lethal dose (50 percent kill): 170 mg/kgNEZTAF 47,150,1999
unreported route/rat lethal dose (50 percent kill): 150 mg/kgNEZTAF 47,150,1999

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 91 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		GISAAA 45(6),86,1980
oral/rat lowest published toxic dose: 3 gm/kg/10D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in ovarian weight		JACTDZ 7(5),675,1988
oral/rat lowest published toxic dose: 70 mg/kg/4W- continuousCardiac: Other changes

Vascular: BP elevation not characterized in autonomic section		VCVN1* -,138,1988
oral/rat lowest published toxic dose: 84 mg/kg/24W- intermittentBehavioral: Alteration of classical conditioning

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		VCVN1* -,138,1988
subcutaneous/rat lowest published toxic dose: 280 mg/kg/4W- intermittentLiver: Other changes

Endocrine: Other changes

Blood: Changes in leukocyte (WBC) count		VCVN1* -,138,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg(Ba)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWJTEHD6 4,395,2001
TOXICOLOGY REVIEWHBTME* ,407,2007
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Ba)/m3DTLVS* 3,21,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Ba)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Ba)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Ba)/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.5 mg(Ba)/m3, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(Ba)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg(Ba)/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 mg(Ba)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.3 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Ba)/m3, KZG-week 1 mg(Ba)/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Ba)/m3, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 08650; Number of Industries 62; Total Number of Facilities 4299; Number of Occupations 62; Total Number of Employees Exposed 57997; Total Number of Female Employees Exposed 15249
National Occupational Hazard Survey 1974Hazard Code 08650; Number of Industries 46; Total Number of Facilities 1971; Number of Occupations 30; Total Number of Employees Exposed 13339

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

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