Registry of Toxic Effects of Chemical Substances (RTECS)

2H-Azepin-2-one, hexahydro-

RTECS #

CM3675000

CAS #

105-60-2

Updated

September 201

Molecular Weight

113.18

Molecular Formula

C₆H₁₁NO

Synonyms

1,6-Hexolactam
1-Aza-2-cycloheptanone
2-Azacycloheptanone
2H-Azepin-7-one, hexahydro-
2-Ketohexamethyleneimine
2-Ketohexamethylenimine
2-Oxohexamethyleneimine
2-Oxohexamethylenimine
2-Perhydroazepinone
6-Aminocaproic acid lactam
6-Aminohexanoic acid cyclic lactam
6-Caprolactam
6-Hexanelactam
A1030
Aminocaproic lactam
Caprolactam
Caprolactam monomer
Caprolactam, fume
Caprolattame (French)
Capron PK4
Cyclohexanone iso-oxime
e-Kaprolaktam (Czech)
epsilon-Caprolactam
epsilon-Caprolactam (ACGIH)
Epsylon kaprolaktam (Polish)
Extrom 6N
Hexahydro-2-azepinone
Hexahydro-2H-azepin-2-one (9CI)
Hexamethylenimine, 2-oxo-
Hexanoic acid, 6-amino-, cyclic lactam
Hexanoic acid, 6-amino-, lactam
Hexanolactam
Hexanone isoxime
Hexanonisoxim (German)
Kapromine
NCI-C50646
omega-Caprolactam
Stilon

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,883,1986
skin /rabbit	500 mg/24H	mild	85JCAE -,883,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
body fluid assay	ovary/rat	76 mg/kg	MUREAV 143,263,1985
Cytogenetic Analysis	lymphocyte/human	270 mg/L	PMRSDJ 5,457,1985
Cytogenetic Analysis	lung/hamster	8 gm/L	PMRSDJ 5,427,1985
DNA Damage	intraperitoneal/rat	580 mg/kg	MUREAV 224,379,1989
DNA Damage	intraperitoneal/mouse	580 mg/kg	MUREAV 224,379,1989
DNA inhibition	fibroblast/human	1 mmol/L	NEOLA4 33,699,1986
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	400 mg/L	PMRSDJ 5,271,1985
micronucleus test	multiple/non-mammalian species	100 ppm	MUTAEX 4,17,1989
morphological transform	embryo/hamster	100 mg/L	TIVIEQ 2,103,1988
morphological transform	embryo/mouse	2500 mg/L	PMRSDJ 5,639,1985
mutation in microorganisms	/Saccharomyes cerevisiae	100 mg/L (+/-enzymatic activation step)	PMRSDJ 5,271,1985
phage inhibition capacity	/Escherichia coli	1950 µg/well	MUREAV 260,349,1991
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	5 mmol/L	MUREAV 224,339,1989
sex chromosome loss and nondisjunction	lymphocyte/human	25 mmol/L	MUREAV 224,333,1989
sister chromatid exchange	ovary/hamster	125 mmol/L	MUREAV 224,333,1989
specific locus test	oral/Drosophila melanogaster	5 mmol/L	PMRSDJ 5,313,1985
specific locus test	intraperitoneal/mouse	500 mg/kg	MUREAV 224,369,1989
sperm morphology	inhalation/rat	125 mg/m³/10W	GTPZAB 19(10),40,1975

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	125 mg/m³/24H (76D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	GTPZAB 19(10),40,1975
inhalation/rat	473 mg/m³/4H (1-5D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetal death	GISAAA 34(7),25,1969
inhalation/rat	139 mg/m³/4H (6-12D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	GISAAA 34(7),25,1969
inhalation/rat	473 mg/m³/4H (60D prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders	GTPZAB 13(10),22,1969
oral/rabbit	3450 mg/kg (6-28D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JJATDK 7,317,1987
oral/rabbit	2500 mg/kg (6-15D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** OTS0537802
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JJATDK 7,317,1987
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** OTS0537802
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NTIS** OTS0557708

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 100 ppm	Lung, Thorax, or Respiration: Cough	AIHAAP 34,384,1973
inhalation/mouse	lethal concentration (50 percent kill): 450 mg/m³	Behavioral: Muscle contraction or spasticity	GTPZAB 10(10),54,1966
inhalation/mouse	lethal concentration (50 percent kill): 450 mg/m³		TOVEFN (1),20,2001
inhalation/rat	lethal concentration (50 percent kill): 300 mg/m³		TOVEFN (1),20,2001
inhalation/rat	lethal concentration (50 percent kill): 300 mg/m³/2H		85GMAT -,32,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 650 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Antipsychotic Behavioral: Analgesia	JPMSAE 60,1058,1971
intraperitoneal/rat	lowest published lethal dose: 800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature decrease	BJIMAG 11,1,1954
intravenous/mouse	lethal dose (50 percent kill): 480 mg/kg		IMEMDT 39,247,1986
intravenous/rabbit	Lethal dose: >300 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature decrease	BJIMAG 11,1,1954
oral/mouse	lethal dose (50 percent kill): 930 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	GTPZAB 10(10),54,1966
oral/rat	lethal dose (50 percent kill): 1210 mg/kg	Eye: Chromodacryorrhea Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature decrease	NTPTR* NTP-TR-214,1982
skin/rabbit	lethal dose (50 percent kill): 1410 µL/kg		AIHAAP 30,470,1969
skin/rat	lethal dose (50 percent kill): >2 gm/kg		NTIS** OTS0557720
subcutaneous/frog	lowest published lethal dose: 2800 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	AEXPBL 50,199,1903
subcutaneous/guinea pig	lowest published lethal dose: 950 mg/kg		MELAAD 43,124,1952
subcutaneous/mouse	lethal dose (50 percent kill): 750 mg/kg		IMEMDT 39,247,1986
unreported route/mouse	lethal dose (50 percent kill): 930 mg/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990
unreported route/rabbit	lethal dose (50 percent kill): 1 gm/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990
unreported route/rat	lethal dose (50 percent kill): 580 mg/kg	Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased	GISAAA 55(10),33,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 243 mg/m³/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	TOSCF2 44,197,1998
inhalation/rat	lowest published toxic concentration: 5960 mg/kg/82D- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 33(1),22,1968
intraperitoneal/rat	lowest published toxic dose: 9100 mg/kg/26W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in other cell count (unspecified) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	MEPAAX 18,357,1967
oral/rat	lowest published toxic dose: 42 gm/kg/8W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARZNAD 9,9,1959
oral/rat	lowest published toxic dose: 6750 mg/kg/2W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0555505

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not suspected as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal NO EVIDENCE	IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal No Evidence	IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 4	IMEMDT 71,383,1999
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust and vapor), JUL2008
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 40 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (dust), MAR2002
Occupational Exposure Limit-BELGIUM	time-weighted average 2.2 ppm (10 mg/m³), (vapor), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 8.7 ppm (40 mg/m³) (vapor), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 mg/m³ (dust), MAY2011
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (10 mg/m³) (vapor), MAY2011
Occupational Exposure Limit-EC	time-weighted average 10 mg/m³;short term exposure limit 40 mg/m³ (dust, vapor), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³ (dust, vapor), VLE 40 mg/m³ (dust, vapor), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 mg/m³ (dust, vapor, inhal.), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 1 mg/m³, dust, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, 2006
Occupational Exposure Limit-KOREA	time-weighted average 5 ppm (20 mg/m³), short term exposure limit 10 ppm (40 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 mg/m³ (dust), 2004
Occupational Exposure Limit-MEXICO	time-weighted average 5 ppm (20 mg/m³);short term exposure limit 3 mg/m³ (vapor), 2004
Occupational Exposure Limit-MEXICO	short term exposure limit 10 ppm (40 mg/m³) (vapor), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 ppm (23 mg/m³); short term exposure limit 10 ppm (46 mg/m³) (vapor), JAN2002
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³ (dust), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (25 mg/m³), moist, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 10 mg/m³ (dust), JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, (dust, vapour), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³ (dust), 2003
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 20 mg/m³ (fume), 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³ (dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³; short term exposure limit 20 mg/m³ (dust, vapor), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, dust-air	10H time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³	NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, vapor-air	10H time-weighted average 0.22 ppm;short term exposure limit 0.66 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 83732; Number of Industries 12; Total Number of Facilities 812; Number of Occupations 19; Total Number of Employees Exposed 25091; Total Number of Female Employees Exposed 8291
National Occupational Hazard Survey 1974	Hazard Code 83732; Number of Industries 14; Total Number of Facilities 955; Number of Occupations 14; Total Number of Employees Exposed 6208

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat
On EPA IRIS database

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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