Registry of Toxic Effects of Chemical Substances (RTECS)
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Acetonitrile, hydroxy-
RTECS #
AM0350000CAS #
107-16-4Updated
July 2000Molecular Weight
57.06Molecular Formula
C2H3NOSynonyms
2-HydroxyacetonitrileCyanomethanol
Formaldehyde cyanohydrin
Glycolic nitrile
Glycolonitrile (8CI)
Glyconitrile
Glykolonitril (Czech)
Hydroxyacetonitrile
Hydroxyazetonitril (German)
Hydroxymethylkyanid (Czech)
Hydroxymethylnitrile
USAF A-8565
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,915,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | Lowest published lethal concentration: 27 ppm/8H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) | 34ZIAG -,290,1969 |
| inhalation/rat | Lowest published lethal concentration: 27 ppm/8H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) | 34ZIAG -,290,1969 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 3 mg/kg | ZAARAM 19,225,1969 | |
| ocular/rabbit | lowest published lethal dose: 13 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma | 34ZIAG -,290,1969 |
| oral/mouse | lethal dose (50 percent kill): 10 mg/kg | 34ZIAG -,290,1969 | |
| oral/rat | lethal dose (50 percent kill): 8 mg/kg | ZAARAM 19,225,1969 | |
| skin/rabbit | lethal dose (50 percent kill): 5 mg/kg | Skin: After topical application: Primary irritation | AIHAAP 23,95,1962 |
| subcutaneous/mouse | lowest published lethal dose: 15 mg/kg | AIPTAK 12,447,1904 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (5 mg/m3), short term exposure limit 2 ppm, Skin, JAN1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCOLONITRILE-air | ceiling concentration 2.0 ppm/15M | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X6125; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 18; Total Number of Employees Exposed 1433 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9040 | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division