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Major Histocompatibility Complex Antigens (Self-Antigens)

MHC Class I processing

MHC Class I processing

MHC class I pathway: proteins in the cytosol are degraded by the proteasome, liberating peptides internalized by TAP channel in the endoplasmic reticulum, there associating with MHC-I molecules freshly synthesized. MHC-I/peptide complexes enter Golgi apparatus, are glycosylated, enter secratory vesicles, fuse with the cell membrane, and externalize on the cell membrane interacting with T lymphocytes.

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Related Terms

  • human leukocyte antigen (HLA)
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