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Boundless Anatomy and Physiology
APPENDIX B: Development and Aging of the Organ Systems
Development of the Skeleton
Physiology Textbooks Boundless Anatomy and Physiology APPENDIX B: Development and Aging of the Organ Systems Development of the Skeleton
Physiology Textbooks Boundless Anatomy and Physiology APPENDIX B: Development and Aging of the Organ Systems
Physiology Textbooks Boundless Anatomy and Physiology
Physiology Textbooks
Physiology
Concept Version 12
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Aging and the Skeleton

In osteoporosis, bone mineral density (BMD) is reduced and the integrity of bone proteins is altered, increasing the risk of fracture.

Learning Objective

  • Construct a diagnosis of osteoporosis and a treatment plan for preventing it


Key Points

    • The risk of osteoporosis can be reduced with lifestyle changes and sometimes medication, both aimed at restoring the amounts and types of necessary bone-associated proteins.
    • Osteoporosis itself has no symptoms; its main consequence is the increased risk of bone fractures.
    • Treatments for osteoporosis include changes in diet and exercise, increased consumption of calcium and vitamin D, and prescriptions for bisphosphonates.

Terms

  • bone mineral density

    Bone mineral density (BMD) is a medical term referring to the amount of mineral matter per square centimeter of bone. BMD is used in clinical medicine as an indirect indicator of osteoporosis and fracture risk.

  • osteoporosis

    A disease, occurring especially in women following menopause, in which the bones become extremely porous and are subject to fracture.

  • bisphosphonates

    Bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis.


Full Text

Osteoporosis

Osteoporosis is a disease of bones that leads to an increased risk of fracture . In osteoporosis, the bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone is altered. The disease may be classified as primary type one, primary type two, or secondary. The form of osteoporosis most common in women after menopause is referred to as primary type one or postmenopausal osteoporosis.

Osteoporotic Fractures

Image shows compression fractures of the lumbar spine.

Primary type two osteoporosis or senile osteoporosis occurs after age 75 and is seen in both females and males at a ratio of two to one. Finally, secondary osteoporosis may arise at any age and affect men and women equally. This form of osteoporosis results from chronic predisposing medical problems or disease, or prolonged use of medications such as glucocorticoids. Osteoporosis affects 55% of Americans aged 50 and above. Of these, approximately 80% are women.

Symptoms

Osteoporosis itself has no symptoms; its main consequence is the increased risk of weakened bones and consequent fractures. Osteoporotic fractures are those that occur in situations where healthy people would not normally break a bone. Physical deformation can occur secondary to compromised bone densities. One example is Hyperkyphosis, colloquially called a "dowager's hump", which refers to an anteriorly concave, curvature of the thoracic region of the spine . Fractures resulting from osteoporosis are regarded as fragility fractures. Typical fragility fractures occur in the vertebral column, rib, hip, and wrist. The underlying mechanism in all cases of osteoporosis is an imbalance between bone resorption and bone formation.

Woman with Osteoporosis

Hyperkyphosis, colloquially called a "dowager's hump,, refers to an anteriorly concave, curvature of the thoracic region of the spine.

Treatment

Osteoporosis risks can be reduced with lifestyle changes and sometimes medication. In people with osteoporosis, treatment may involve both. Lifestyle change includes diet and exercise, and preventing falls. Medication includes calcium, vitamin D, bisphosphonates, and several others. Fall-prevention advice includes exercise to tone deambulatory muscles and proprioception-improvement (body orientation sense) exercises. Equilibrium therapies may be included. Exercise with its anabolic effect may, at the same time, stop or reverse osteoporosis.

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