estradiol

(noun)

A potent estrogenic hormone ((17)-estra-1,3,5-triene-3,17-diol) produced in the ovaries of female vertebrates; the synthetic compound is used medicinally to treat estrogen deficiency and breast cancer.

Related Terms

Examples of estradiol in the following topics:

  • Puberty

    • While testosterone produces all boys' changes characterized as virilization, a substantial product of testosterone metabolism in males is estradiol.
    • The conversion of testosterone to estradiol depends on the amount of body fat and estradiol levels in boys are typically much lower than in girls.
    • The hormone that dominates female development is an estrogen called estradiol.
    • While estradiol promotes growth of breasts and uterus, it is also the principal hormone driving the pubertal growth spurt and epiphyseal maturation and closure.
    • Estradiol levels rise earlier and reach higher levels in women than in men.

  • Aging and the Endocrine System

    • Three hormone axes are affected by aging: growth hormone/insulin-like growth factor I, cortisol/dehydroepiandrosterone, and testoterone/estradiol.
    • Three of the most important hormone axes in the endocrine system that are affected by aging include growth hormone (GH)/insulin-like growth factor I (IGF-I), cortisol/dehydroepiandrosterone (DHEA), and testosterone/estradiol.
    • Menopause/andropause refers to the decrease in production and circulation of estradiol (estrogen) in females and testosterone in males.
    • Estradiol is the female equivalent of testosterone and is secreted from granulosa cells.

  • Hormonal Regulation of the Male Reproductive System

    • They are capable of producing the hormones estradiol and inhibin.
    • The Leydig cells are also capable of producing estradiol in addition to their main product, testosterone.

  • Intramuscular Injections

    • Compunds and drugs that are administered via IM injection include: Codeine, Morphine, Methotrexate, Metoclopramide, Olanzapine, Streptomycin, Diazepam, Prednisone, Penicillin, Interferon beta-1a, Sex hormones, such as Testosterone, Estradiol Valerate, and Depo Provera Dimercaprol, Ketamine, Lupron, Naloxone, and Quinine, in its gluconate form Vitamin B12, also known as cyanocobalamin.

  • Administering Hormones

  • Menopause

    • Menopause is based on the natural or surgical cessation of estradiol and progesterone production by the ovaries, which are a part of the body's endocrine system of hormone production, in this case the hormones which make reproduction possible and influence sexual behavior.
    • However the dramatic fall in circulating estradiol levels at menopause impacts many tissues, from brain to skin.

  • Extrauterine Effects of Estrogens and Progesterone

    • The three major naturally occurring forms of estrogen in women are estrone (E1), estradiol (E2), and estriol (E3).

  • Male and Female Gonads

    • Prior to ovulation, follicle-stimulating hormone is secreted by the granulosal cells that convert testosterone into estradiol.

  • Male Sexual Response

    • Several hormones affect sexual arousal, including testosterone, cortisol, and estradiol.

  • Pituitary Gland Disorders

    • Once the effector glands produce sufficient hormones (thyroxine, cortisol, estradiol or testosterone and IGF-1), both the hypothalamus and the pituitary cells sense their abundance and reduce their secretion of stimulating hormones.