open reading frame

(noun)

A sequence of DNA triplets, between the initiator and terminator codons, that can be transcribed into mRNA and later translated into protein.

Related Terms

  • codons
  • gene

Examples of open reading frame in the following topics:

  • Size Variation and ORF Contents in Genomes

    • An open reading frame (ORF) is the part of a reading frame that varies in size and content in bacterial genomes.
    • In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons.
    • Open reading frames are used as one piece of evidence to assist in gene prediction.
    • Even a long open reading frame by itself is not conclusive evidence for the presence of a gene.
    • In this sequence two out of three possible reading frames are entirely open, meaning that they do not contain a stop codon:
  • Unsticking Stuck Ribosomes

    • The tmRNP binds to the A-site, allowing the ribosome to switch templates from the broken message onto the open reading frame of the tmRNA via the resume codon (blue GCA).
  • Respiratory Syncytial Virus Infection

    • There are two open reading frames of M2.
  • Temperate Bacteriophages: Lambda and P1

    • Note how sib is displaced by the recombination event from the N extended PL promoter open reading frame.
  • Double-Stranded DNA Viruses: Herpesviruses

    • HSV-1 and HSV-2 each contain at least 74 genes within their genomes, although speculation over gene crowding allows as many as 84 unique protein-coding genes by 94 putative pen reading frames.
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