integrin

(noun)

Any of many heterodimeric transmembrane proteins that function as receptors in communication between cells.

Related Terms

  • penton
  • recombinant DNA
  • endosome
  • capsid

Examples of integrin in the following topics:

  • HIV Attachment and Host Cell Entry

    • The HIV coat protein, gp120, binds to integrin α4β7, activating LFA-1 (the central integrin involved in the establishment of bridges known as "virological synapses") which facilitate efficient cell-to-cell spreading of HIV-1.
  • Planctomycetes

    • One such example is a gene sequence (in Gemmata obscuriglobus) that was found to have significant homology to the integrin alpha-V, a protein that is important in transmembrane signal transduction in eukaryotes.
  • Double-Stranded DNA Viruses: Adenoviruses

    • Next, a specialized motif in the penton base protein interacts with αv integrin, stimulating internalization of the adenovirus via clathrin-coated pits, resulting in entry of the virion into the host cell within an endosome.
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