beta sheet

(noun)

A secondary structure in proteins consisting of multiple strands connected laterally.

Related Terms

  • alpha helix
  • prion

Examples of beta sheet in the following topics:

  • RNA Bacteriophages

    • They adopt a secondary structure consisting of a six-stranded beta sheet and an alpha helix.
  • Prions

    • All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly-packed beta sheets.
  • Antibody Proteins and Antigen Binding

    • All chains have a characteristic immunoglobulin fold in which two beta sheets create a "sandwich" shape, held together by interactions between conserved cysteines and other charged amino acids.
  • Bovine Spongiform Encephalopathy

    • TSEs can arise in animals that carry an allele which causes previously normal protein molecules to contort by themselves from an alpha helix arrangement to a beta sheet, which is the disease-causing shape for the particular protein.
  • Variant Creutzfeldt-Jakob Disease

    • Mutations in the gene for the prion protein can cause a misfolding of the dominantly alpha helical regions into beta pleated sheets.
  • T Cell Receptors

    • The antigen receptor of MHC-restricted CD4 helper T cells and CD8 cytolytic T cell is a heterodimer consisting of two transmembrane polypeptide chains, designated alpha and beta, covalently linked to each other by disulfide bonds.
    • Each alpha and beta chain consists of one variable domain (V), one constant domain (C), a hydrophobic transmembrane region, and a short cytoplasmic region .
    • The recognition of peptide-MHC complexes is mediated by CDRs formed by both the alpha and beta chains of the TCR.
    • T cell receptor consists of alpha and beta chains, a transmembrane domain, and a cytoplasmic region.
  • Inhibiting Cell Wall Synthesis

    • β-Lactam (beta-lactam) and glycopeptide antibiotics work by inhibiting or interfering with cell wall synthesis of the target bacteria.
    • The first class of antimicrobial drugs that interfere with cell wall synthesis are the β-Lactam antibiotics (beta-lactam antibiotics), consisting of all antibiotic agents that contains a β-lactam nucleus in their molecular structures.
    • Describe the two types of antimicrobial drugs that inhibit cell wall synthesis: beta-lactam and glycopeptide antibiotics
  • Beta-Lactam Antibiotics: Penicillins and Cephalosporins

    • A β-lactam (beta-lactam) ring, is a four-membered lactam .
  • The Incorporation of Nonstandard Amino Acids

    • It is important to compare the structures of alanine and beta alanine.
    • In alanine, the side-chain is a methyl group; in beta alanine, the side-chain contains a methylene group connected to an amino group, and the alpha carbon lacks an amino group.
    • A rare exception to the dominance of α-amino acids in biology is the β-amino acid beta alanine (3-aminopropanoic acid), which is used in plants and microorganisms in the synthesis of pantothenic acid (vitamin B5), a component of coenzyme A.
  • Bacterial Skin Diseases

    • Most cases of erysipelas are due to Streptococcus pyogenes (also known as beta-hemolytic group A streptococci), although non-group A streptococci can also be the causative agent.
    • Beta-hemolytic, non-group A streptococci include Streptococcus agalactiae, also known as group B strep or GBS.
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