thyroglobulin

Examples of thyroglobulin in the following topics:

• Formation, Storage, and Release of Thyroid Hormones

  • Thyroglobulin, the pre-cursor of T4 and T3, is produced by the thyroid follicular cells before being secreted and stored in the follicular lumen.
  • Through a reaction with the enzyme thyroperoxidase, iodine is bound to tyrosine residues in the thyroglobulin molecules to form monoiodotyrosine (MIT) and diiodotyrosine (DIT).
  • Proteases digest iodinated thyroglobulin, releasing the hormones T4 and T3, the biologically-active agents central to metabolic regulation.

• Thyroid Gland

  • These follicles contain a viscous fluid, called colloid, which stores the glycoprotein thyroglobulin.

• Development of the Endocrine System

  • An enzymatic splitting of the thyroxine from the thyroglobulin occurs when a specific hormone is released into the blood.

• RNA and Protein Synthesis

  • Other important functional changes include iodination of tyrosine residues in the peptide thyroglobulin by action of the enzyme thyroperoxidase.