polyadenylation

(noun)

The formation of a polyadenylate, especially that of a nucleic acid

Related Terms

  • Kozak sequence
  • transcription

Examples of polyadenylation in the following topics:

  • Vectors for Genomic Cloning and Sequencing

    • These plasmid transcription vectors characteristically lack crucial sequences that code for polyadenylation sequences and translation termination sequences in translated mRNAs, making protein expression from transcription vectors impossible.
  • Unsticking Stuck Ribosomes

    • Stuck mRNA transcripts can arise from many different mechanisms such as premature 3' adenylation or cryptic polyadenylation signals within the coding region of a gene.
  • Plasmids as Cloning Vectors

    • A polyadenylation tail at the end of the transcribed pre-mRNA: This protects the mRNA from exonucleases and ensures transcriptional and translational termination and stabilizes mRNA production.
  • Prions

    • The endogenous, properly-folded form is denoted PrPC (for Common or Cellular) while the disease-linked, misfolded form is denoted PrPSc (for Scrapie, after one of the diseases first linked to prions and neurodegeneration. ) The precise structure of the prion is not known, though they can be formed by combining PrPC, polyadenylic acid, and lipids in a Protein Misfolding Cyclic Amplification (PMCA) reaction.
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