labile

(adjective)

A property of transient chemical species that enables rapid synthesis and degradation of substrates in biological systems.

Related Terms

  • Metalloprotein
  • enzyme
  • cofactor

Examples of labile in the following topics:

  • Reactions of Coordination Compounds

    • Complexes where the ligands are released and rebound rapidly are classified as labile.
    • Such labile complexes can be quite stable thermodynamically.
    • The lability of a metal complex also depends on the high-spin vs. low-spin configurations when such is possible.
    • Thus, high-spin Fe(II) and Co(III) form labile complexes, whereas low-spin analogues are inert.
  • Charge Separation

    • Because electrons are labile (i.e., they can be transferred from atom to atom) it is possible for the phenomenon of "charge separation" (often referred to as static electricity) to occur.
  • Filtration

    • This method is commonly used for heat labile pharmaceuticals and for protein solutions in processing medicines.
  • RBC Anatomy

    • RBCs therefore cannot divide or replicate like other labile cells of the body.
  • Nitrogen Fixation Mechanism

    • Component I known as MoFe protein or nitrogenase contains 2 Mo atoms, 28 to 34 Fe atoms, and 26 to 28 acid-labile sulfides, also known as a iron-molybdenum cofactor (FeMoco).
    • This protein has four non-heme Fe atoms and four acid-labile sulfides (4Fe-4S).
  • Nucleophilic Substitution

    • Typically, strength of a leaving group's conjugate acid correlates with its lability.
    • The only criterion is that they are labile enough to be "pushed" away by the nucleophile.
  • Biomolecules

    • Metalloenzymes contain a metal ion bound to the protein with one labile coordination site.
  • Positive-Strand RNA Viruses of Animals

    • In contrast, rhinoviruses are acid-labile (inactivated or destroyed by low pH conditions) and that is the reason why rhinovirus infections are restricted to the nose and throat.
  • Electric Charge in the Atom

    • More important is the fact that electrons are labile; that is, they can be transferred from one atom to the next.
  • Reactions of Alcohols

    • A similar reaction can be performed using PBr3 or SOCl2 (for bromination and chlorination, respectively) as agents to make the hydroxyl more labile.
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