integrin

Microbiology

(noun)

Any of many heterodimeric transmembrane proteins that function as receptors in communication between cells.

Related Terms

  • penton
  • recombinant DNA
  • endosome
  • capsid
Physiology

(noun)

Is a transmembrane receptor that mediates the attachment between a cell and the tissues that surround it, such as other cells or the extracellular matrix (ECM).

Related Terms

  • keratinocyte
  • hemidesmosome

Examples of integrin in the following topics:

  • Hemidesmosomes

    • An example configuration of a hemidesmosome might consist of cytosolic keratin, non-covalently bonded to a cytosolic plectin plaque, which is bonded to a single-pass transmembrane adhesion molecule such as the α6β4 integrin.
    • The integrin might then attach to one of many multi-adhesive proteins such as laminin, resident within the extracellular matrix, thereby forming one of many potential adhesions between cell and matrix.
  • HIV Attachment and Host Cell Entry

    • The HIV coat protein, gp120, binds to integrin α4β7, activating LFA-1 (the central integrin involved in the establishment of bridges known as "virological synapses") which facilitate efficient cell-to-cell spreading of HIV-1.
  • Planctomycetes

    • One such example is a gene sequence (in Gemmata obscuriglobus) that was found to have significant homology to the integrin alpha-V, a protein that is important in transmembrane signal transduction in eukaryotes.
  • Basement Membranes and Diseases

    • It is caused by a mutation in the integrin α6β4 cell-adhesion molecule on either the alpha or beta subunit.
  • Double-Stranded DNA Viruses: Adenoviruses

    • Next, a specialized motif in the penton base protein interacts with αv integrin, stimulating internalization of the adenovirus via clathrin-coated pits, resulting in entry of the virion into the host cell within an endosome.
  • Development of the Immune System

    • This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium.
  • Fluid Mosaic Model

    • Integral proteins (some specialized types are called integrins) are, as their name suggests, integrated completely into the membrane structure, and their hydrophobic membrane-spanning regions interact with the hydrophobic region of the the phospholipid bilayer .
  • Inflammation

    • Then, integrins will firmly attach to the adhesion molecules on the endothelial cells, which is called adhesion.
  • Mammary Glands

    • Laminin and collagen in myoepithelial basement membrane interacting with beta-1 integrin on epithelial surface again, is essential in this process.
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