cadherin

(noun)

Any of a class of transmembrane proteins important in maintaining tissue structure.

Related Terms

  • catenin
  • adherens junctions

Examples of cadherin in the following topics:

  • Adherens Junctions

    • They link the actin microfilaments to the cadherins.
    • Cadherins, namely E-cadherin. 
    • The extracellular part of one cell’s cadherin binds to the extracellular part of the adjacent cell’s cadherin in the space between the two cells. 
    • Each cell’s cadherin molecule also contains a tail that inserts itself inside its respective cell. 
    • This intracellular (within the cell) tail then links up to catenin proteins to form the cadherin–catenin complex. 
  • Desmosomes

    • The cell adhesion proteins of the desmosome - desmoglein and desmocollin - are members of the cadherin family of cell adhesion molecules.
    • They are transmembrane proteins that bridge the space between adjacent epithelial cells by way of homophilic binding of their extracellular domains to other desmosomal cadherins on the adjacent cell.
    • The Outer Dense Plaque is where the cytoplasmic domains of the cadherins attach to desmoplakin via plakoglobin and plakophillin.
  • Intercellular Junctions

    • Short proteins called cadherins in the plasma membrane connect to intermediate filaments to create desmosomes.
    • The cadherins join two adjacent cells together and maintain the cells in a sheet-like formation in organs and tissues that stretch, such as the skin, heart, and muscles.
    • It is created by the linkage of cadherins and intermediate filaments.
  • Listeriosis

    • This involves a bacterial protein "internalin" which attaches to a protein on the intestinal cell membrane "cadherin. " These adhesion molecules are also to be found in two other unusually tough barriers in humans - the blood-brain barrier and the feto-placental barrier, and this may explain the apparent affinity that Listeria has for causing meningitis and affecting babies in-utero.
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