beta-lactamase

(noun)

An enzyme produced by certain bacteria, responsible for their resistance to beta-lactam antibiotics such as penicillin.

Related Terms

  • antibiotic

Examples of beta-lactamase in the following topics:

  • Antibiotics from Prokaryotes

    • Clavulanic acid (from S. clavuligerus) is a drug used in combination with some antibiotics (like amoxicillin) to block and/or weaken some bacterial-resistance mechanisms by irreversible beta-lactamase inhibition.
  • Shuttle Vectors and Expression Vectors

    • The E. coli component of a yeast shuttle vector includes an origin of replication and a selectable marker, such as an antibiotic resistance like beta lactamase.
  • Inhibiting Cell Wall Synthesis

    • β-Lactam (beta-lactam) and glycopeptide antibiotics work by inhibiting or interfering with cell wall synthesis of the target bacteria.
    • The first class of antimicrobial drugs that interfere with cell wall synthesis are the β-Lactam antibiotics (beta-lactam antibiotics), consisting of all antibiotic agents that contains a β-lactam nucleus in their molecular structures.
    • Bacteria often develop resistance to β-lactam antibiotics by synthesizing a β-lactamase, an enzyme that attacks the β-lactam ring.
    • To overcome this resistance, β-lactam antibiotics are often given with β-lactamase inhibitors such as clavulanic acid.
    • Describe the two types of antimicrobial drugs that inhibit cell wall synthesis: beta-lactam and glycopeptide antibiotics
  • Beta-Lactam Antibiotics: Penicillins and Cephalosporins

    • A β-lactam (beta-lactam) ring, is a four-membered lactam .
    • They do this by expressing the β-lactamase gene.
  • Beta Decay

    • Beta decay is a type of radioactive decay in which a beta particle (an electron or a positron) is emitted from an atomic nucleus.
    • There are two types of beta decay.
    • Beta minus (β) leads to an electron emission (e−); beta plus (β+) leads to a positron emission (e+).
    • Beta decay is mediated by the weak force.
    • The continuous energy spectra of beta particles occur because Q is shared between a beta particle and a neutrino.
  • The Fields

    • $\displaystyle \beta \equiv \frac{\bf u}{c},~\text{so}~ \kappa = 1 - {\bf n} \cdot \beta$
    • $\displaystyle {\bf E}(r,t) = \kern-2mm q \left [ \frac{({\bf n} - \beta)(1-\beta^2)}{\kappa^3 R^2} \right ]_\mathrm{ret}\!
    • \frac{q}{c} \left [ \frac{\bf n}{\kappa^3 R} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]\right ]_\mathrm{ret} \\ {\bf B}(r,t) = \kern-2mm\left [ {\bf n} \times {\bf E}(r,t) \right ]_\mathrm{ret}.$
    • $\displaystyle {\bf E}_{rad}(r,t) = + \frac{q}{c} \left [ \frac{\bf n}{\kappa^3 R} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]\right ] \\ {\bf B}_{rad}(r,t) = \left [ {\bf n} \times {\bf E}_{rad}(r,t) \right ].$
    • $\displaystyle {\bf S} = {\bf n} \frac{q^2}{4\pi c \kappa^6 R^2} \left | {\bf n} \times \left \{ \left ( {\bf n} - \beta \right ) \times {\dot{\beta}} \right \} \right |^2$
  • Angle Addition and Subtraction Formulae

    • $\begin{aligned} \cos(\alpha + \beta) &= \cos \alpha \cos \beta - \sin \alpha \sin \beta \\ \cos(\alpha - \beta) &= \cos \alpha \cos \beta + \sin \alpha \sin \beta \end{aligned}$
    • $\begin{aligned} \sin(\alpha + \beta) &= \sin \alpha \cos \beta + \cos \alpha \sin \beta \\ \sin(\alpha - \beta) &= \sin \alpha \cos \beta - \cos \alpha \sin \beta \end{aligned}$
    • $\displaystyle{ \begin{aligned} \tan(\alpha + \beta) &= \frac{ \tan \alpha + \tan \beta}{1 - \tan \alpha \tan \beta} \\ \tan(\alpha - \beta) &= \frac{ \tan \alpha - \tan \beta}{1 + \tan \alpha \tan \beta} \end{aligned} }$
    • Apply the formula $\cos(\alpha - \beta) = \cos \alpha \cos \beta + \sin \alpha \sin \beta$:
    • We can thus apply the formula for sine of the difference of two angles: $\sin(\alpha - \beta) = \sin \alpha \cos \beta - \cos \alpha \sin \beta$.
  • Distribution in Frequency and Angle

    • $\displaystyle R {\hat E} (\omega) = \frac{q}{2\pi c} \int_{-\infty}^{\infty} \left [ \frac{\bf n}{\kappa^3} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]\right ]_\mathrm{ret} e^{i\omega t} d t.$
    • $\displaystyle R {\hat E} (\omega) = \frac{q}{2\pi c} \int_{-\infty}^{\infty} \left [ \frac{\bf n}{\kappa^2} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]\right ] e^{i\omega (t'+R(t')/c)} d t'.$
    • $\displaystyle R {\hat E} (\omega) = \frac{q}{2\pi c} \int_{-\infty}^{\infty} \left [ \frac{\bf n}{\kappa^2} \times \left [ ({\bf n} - \beta) \times \dot{\beta} \right ]\right ] e^{i\omega (t'-{\bf n}\cdot {\bf r}(t')/c)} d t'.$
    • $\displaystyle \frac{d W}{d\Omega d\omega} = \frac{q^2}{4\pi^2 c} \left | \int_{-\infty}^{\infty} \frac{{\bf n} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]}{\left ( 1-\beta\cdot {\bf n} \right )^2} e^{i\omega (t'-{\bf n}\cdot {\bf r}(t')/c)} d t' \right |.$
    • $\displaystyle \frac{{\bf n} \times \left [ ({\bf n} - \beta ) \times \dot{\beta} \right ]}{\left ( 1-\beta\cdot {\bf n} \right )^2} = \frac{d}{d t'} \left [ \frac{{\bf n} \times ({\bf n} \times \beta ) }{1-\beta\cdot {\bf n}} \right ].$
  • Beta Coefficient for Portfolios

    • A portfolio's Beta is the volatility correlated to an underlying index.
    • A portfolio's Beta is the volatility correlated to an underlying index.
    • What would the following portfolios have for Beta values?
    • Thus, the portfolio would have a Beta value of 3.
    • Two hypothetical portfolios; what do you think each Beta value is?
  • Inverse Compton Spectra - Single Scattering

    • $\displaystyle I'(E',\mu') = F_0 \left (\frac{E'}{E}\right)^2 \delta (E-E_0)\\ \displaystyle = F_0 \left (\frac{E'}{E_0}\right)^2 \delta (\gamma E' (1+\beta\mu') -E_0) \\ \displaystyle = \frac{F_0}{\gamma\beta E'} \left (\frac{E'}{E_0}\right)^2 \delta \left (\mu' - \frac{E_0-\gamma E'}{\gamma\beta E'} \right )$
    • $\displaystyle j'(E_f') = \frac{N' \sigma_T E_f' F_0}{2 E_0^2 \gamma \beta}~\text{ if }~ \frac{E_0}{\gamma (1+\beta)} < E_f' < \frac{E_0}{\gamma(1-\beta)}$
    • $\displaystyle j(E_f,\mu_f) = \frac{E_f}{E_f'} j'(E_f') \\ \displaystyle = \frac{N \sigma_T E_f F_0}{2 E_0^2 \gamma^2 \beta} \\ \displaystyle ~~\text{ if }~ \frac{E_0}{\gamma (1+\beta)(1-\beta \mu_f)} < E_f < \frac{E_0}{\gamma(1-\beta)(1-\beta \mu_f)} \nonumber$
    • $\displaystyle \frac{1}{\beta} \left [ 1 - \frac{E_0}{E_f} \left ( 1 + \beta \right ) \right ] < \mu_f < \frac{1}{\beta} \left [ 1 - \frac{E_0}{E_f} \left ( 1 - \beta \right ) \right ].$
    • $\displaystyle j(E_f) = \frac{N \sigma_T F_0}{4 E_0 \gamma^2 \beta^2} \left \{ \begin{array}{lc} (1+\beta) \frac{E_f}{E_0} - (1 -\beta ), \frac{1-\beta}{1+\beta} < \frac{E_f}{E_0} < 1 \\ \displaystyle (1+\beta) - \frac{E_f}{E_0} (1 -\beta ), 1 < \frac{E_f}{E_0} < \frac{1+\beta}{1-\beta} \\ \displaystyle 0, \text{ otherwise } \end{array} \right .$
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