prion

(noun)

a self-propagating misfolded conformer of a protein that is responsible for a number of diseases that affect the brain and other neural tissue

Related Terms

  • chaperone
  • proteinaceous
  • viroid

Examples of prion in the following topics:

  • Prions and Viroids

    • Prions are infectious particles that contain no nucleic acids, and viroids are small plant pathogens that do not encode proteins.
    • Prions, so-called because they are proteinaceous, are infectious particles, smaller than viruses, that contain no nucleic acids (neither DNA nor RNA).
    • It is this variant that constitutes the prion particle.
    • Once introduced into the body, the PrPsc contained within the prion binds to PrPc and converts it to PrPsc.
    • (a) Endogenous normal prion protein (PrPc) is converted into the disease-causing form (PrPsc) when it encounters this variant form of the protein.
  • Protein Folding, Modification, and Targeting

    • A misfolded protein, known as prion, appears to be the agent of a number of rare degenerative brain diseases in mammals, like the mad cow disease.
    • Prion, the misfolded protein, is a normal constituent of brain tissue in all mammals, but its function is not yet known.
    • Prions cannot reproduce independently and not considered living microoganisms.
    • A complete understanding of prion diseases awaits new information about how prion protein affects brain function, as well as more detailed structural information about the protein.
Subjects
  • Accounting
  • Algebra
  • Art History
  • Biology
  • Business
  • Calculus
  • Chemistry
  • Communications
  • Economics
  • Finance
  • Management
  • Marketing
  • Microbiology
  • Physics
  • Physiology
  • Political Science
  • Psychology
  • Sociology
  • Statistics
  • U.S. History
  • World History
  • Writing

Except where noted, content and user contributions on this site are licensed under CC BY-SA 4.0 with attribution required.