isotype

Examples of isotype in the following topics:

• Isotype Class Switching

  • Antibodies can come in different varieties, known as isotypes or classes.
  • In placental mammals there are five antibody isotypes: IgA, IgD, IgE, IgG and IgM.
  • The antibody isotype of a B cell changes during cell development and activation.
  • Immunoglobulin class switching (or isotype switching, or isotypic commutation, or class switch recombination (CSR)) is a biological mechanism that changes a B cell's production of antibody from one class to another; for example, from an isotype called IgM to an isotype called IgG.
  • Mechanism of class switch recombination that allows isotype switching in activated B cells.

• Antibody Genes and Diversity

  • There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess.
  • Five different antibody isotypes are known in mammals, which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter.
  • This creates a different isotype of the antibody while retaining the antigen specific variable region, thus allowing a single antibody to be used by several different parts of the immune system.

• Antibody Proteins and Antigen Binding

  • There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess .
  • Five different antibody isotypes are known in mammals, which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter.

• Primary Immunodeficiency Diseases

  • In primary antibody deficiencies, one or more isotypes of immunoglobulin are decreased or don't function properly.