phagosome

Examples of phagosome in the following topics:

• Microbial Evasion of Phagocytosis

  • Some bacteria prevent the fusion of a phagosome and lysosome from forming the phagolysosome.
  • Legionella pneumophila produces secretions which cause the phagosome to fuse with vesicles other than the ones that contain toxic substances.
  • Bacteria may escape from the phagosome before the formation of the phagolysosome.
  • Listeria monocytogenes can make a hole in the phagosome wall using enzymes.
  • After a bacterium is ingested, it may kill the phagocyte by releasing toxins that travel through the phagosome or phagolysosome membrane to target other parts of the cell.

• Phagocyte Migration and Phagocytosis

  • Once inside the phagocyte, the bacterium is trapped in a compartment called a phagosome.
  • Within one minute the phagosome merges with either a lysosome or a granule, to form a phagolysosome.

• Cell Structure, Metabolism, and Motility

  • The vesicle containing the ingested particle, the phagosome, then fuses with a lysosome containing hydrolytic enzymes to produce a phagolysosome, which breaks down the food particle into small molecules that diffuse into the cytoplasm for use in cellular metabolism.

• Phagocytes

  • The engulfed pathogen is kept in a vacuole called a phagosome, which then binds to the lysosomes inside the cell.