Plasmin

(noun)

A protease that breaks down plasmin. It is cleaved from inactive plasminogen.

Related Terms

  • fibrin
  • protease
  • coagulation

Examples of Plasmin in the following topics:

  • Fibrinolysis

    • The main enzyme in primary fibrinolysis is plasmin, a proteolytic enzyme that degrades fibrin mesh.
    • Plasmin is produced in an inactive form, plasminogen, in the liver.
    • Instead, it is incorporated into the clot when it is formed and then activated into plasmin later.
    • In contrast, plasmin further stimulates plasmin generation by producing more active forms of both tissue plasminogen activator (tPA) and urokinase.
    • Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin.
  • Blood Plasma

    • Normally, anticoagulants and fibrinolytics in the plasma, such as plasmin and heparin, break up fibrin clots and inactivate thrombin.
  • Coagulation

    • Plasmin: generated by proteolytic cleavage of plasminogen, a potent fibrinolytic that degrades fibrin and destroys clots.
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