muscarinic

(noun)

Acetylcholine receptors that can be both excitatory and inhibitory.

Related Terms

  • nicotinic
  • peripheral nervous system
  • mixed spinal nerve

Examples of muscarinic in the following topics:

  • Agonists, Antagonists, and Drugs

    • ACh binds to muscarinic receptors (M2) that are found principally on cells comprising the sinoatrial (SA) and atrioventricular (AV) nodes.
    • Muscarinic receptors are coupled to the Gi-protein; therefore, vagal activation decreases cAMP.
    • Muscarinic receptor antagonists bind to muscarinic receptors thereby preventing ACh from binding to and activating the receptor.
    • By blocking the actions of ACh, muscarinic receptor antagonists very effectively block the effects of vagal nerve activity on the heart.
    • Atropine's pharmacological effects are due to binding to muscarinic acetylcholine receptors.
  • Parasympathetic Responses

    • The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic receptors.
    • The postganglionic nerve then releases ACh to stimulate the muscarinic receptors of the target organ.
  • Postganglionic Neurons

    • Postganglionic neurons of sweat glands release acetylcholine for the activation of muscarinic receptors.
    • The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic receptors.
    • The postganglionic nerve then releases ACh to stimulate the muscarinic receptors of the target organ.
  • Cholinergic Neurons and Receptors

    • Although acetylcholine induces contraction of skeletal muscle, it acts via a different type of receptor (muscarinic, see ) to inhibit contraction of cardiac muscle fibers.
    • This human M2 muscarinic acetylcholine receptor is bound to an antagonist
  • Ionotropic and Metabotropic Receptors

    • Examples of metabotropic receptors include glutamate receptors, muscarinic acetylcholine receptors, GABAB receptors, most serotonin receptors, and receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides, and endocannabinoids.
  • Function and Physiology of the Spinal Nerves

    • In the parasympathetic system, ganglionic neurons use acetylcholine as a neurotransmitter to stimulate muscarinic receptors.
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