malignant

(noun)

In relation to cancer, it refers to the tendency of the cancer to become worse, e.g., by spreading throughout the body.

Related Terms

  • benign
  • neoplasm
  • metastasis
  • testicular cancer

(adjective)

Is the tendency of a medical condition, especially tumors, to become progressively worse and to potentially result in death.

Related Terms

  • benign
  • neoplasm
  • metastasis
  • testicular cancer

Examples of malignant in the following topics:

  • Skin Cancer

    • Skin cancers are abnormal growths of skin cells with varying degrees of malignancy.
    • Cancers of the epidermis exhibit varying degrees of malignancy.
    • Warning signs of malignant melanoma include change in the size, shape, color, or elevation of a mole.
    • Even though it is much less common, malignant melanoma is responsible for 75% of all skin cancer-related deaths.
  • Pancreatic Cancer

    • Pancreatic cancer is the uncontrolled growth of malignant cells in tissues forming the pancreas.The most common type is adenocarcinoma.
    • Pancreatic cancer is the uncontrolled growth of malignant cells in the tissues forming the pancreas.
    • If the malignancy is invading or compressing the duodenum or colon, bypass surgery might overcome the obstruction and improve quality of life but is not intended as a cure.
    • The treatment for these, as well as the less common malignant tumors, may include watchful waiting, surgery, hormone therapy, and radiation.
  • Overview of Cancer

    • Cancer, known medically as a malignant neoplasm, is a broad group of various diseases, all involving unregulated cell growth.
    • Cancers comprise the malignant (having a tendency to become worse) subset of neoplasms—a cell or group of cells that undergo unregulated growth and form a mass of tissue—often referred to as a tumor.
    • Non-malignant tumors are referred to as benign; they are typically slower growing and are often surrounded by a membrane of connective tissue that prevents metatasis.
    • Malignant transformation can occur through the formation of novel oncogenes, the inappropriate over-expression of normal oncogenes, or by the under-expression or disabling of tumor suppressor genes.
  • Urinary Bladder Cancer

    • Bladder cancer refers to any type of malignancy arising from the epithelium of the urinary bladder.
    • Bladder cancer is any of several types of malignancy arising from the epithelial lining (i.e., the urothelium) of the urinary bladder.
  • Metastasis Through Lymphatic Vessels

    • Cancer occurs after a single cell in a tissue is progressively genetically damaged to produce a cancer stem cell possessing a malignant phenotype.
    • Malignant cells can break away from the primary tumor and attach to and degrade proteins that make up the surrounding extracellular matrix (ECM).
    • Transcoelomic: The spread of a malignancy into body cavities can occur via seeding the surface of the peritoneal, pleural, pericardial, or subarachnoid spaces.
  • Polyps in the Colon

    • Colon polyps are a concern because of the potential for colon cancer being present microscopically and the risk of benign colon polyps transforming over time into malignant ones.
    • The adenomatous polyp is considered pre-malignant; i.e. likely to develop into colon cancer.
    • Most polyps (approximately 90%) are small, usually less than 1 cm in diameter, and have a small potential for malignancy.
    • Sessile polyps larger than 2 cm usually contain villous features, have a higher malignant potential, and tend to reoccur following colonoscopic polypectomy.
  • Angiogenesis and Disease

    • It is also a fundamental step in the transition of tumors from a dormant state to a malignant one, leading to the use of angiogenesis inhibitors.
    • A malignant tumor consists of a population of rapidly-dividing and growing cancer cells.
    • This mosaicity allows for substantial shedding of tumor cells into the vasculature, possibly contributing to the appearance of circulating tumor cells in the peripheral blood of patients with malignancies.
    • As malignancy develops, cells progress from a prevascular stage (normal to early hyperplasia) to a vascular stage (late hyperplasia to dysplasia to invasive carcinoma).
  • Testicular Cancer

    • Even for the relatively few cases in which malignant cancer has spread widely, modern chemotherapy offers a cure rate of at least 80%.
    • Not all lumps on the testicles are tumors, and not all tumors are malignant; there are many other conditions such as testicular microlithiasis, epididymal cysts, appendix testis (hydatid of Morgagni), and so on which may be painful but are non-cancerous.
  • Cancer Immunology

    • Cancer immunology is the study of interactions between the immune system and cancer cells (also called tumors or malignancies).
    • Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which is an interferon producer causing the patients own killer T cells to destroy warts, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma.
  • Spinal Cord Compression

    • Emergency radiation therapy (usually 20 Gray in five fractions, 30 Gray in 10 fractions or eight Gray in one fraction) is the mainstay of treatment for malignant spinal cord compression.
    • The median survival of patients with metastatic spinal cord compression is about 12 weeks, reflecting the generally advanced nature of the underlying malignant disease.
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