Examples of chondrocyte in the following topics:
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- The chondroblast is now a chondrocyte, which is usually
inactive but can still secrete and degrade the matrix depending on the
conditions.
- Once damaged,
cartilage has limited repair capabilities because chondrocytes are bound in
lacunae and cannot migrate to damaged areas.
- A chondrocyte, stained for calcium, showing its nucleus (N) and mitochondria (M).
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- Chondrocytes in the primary center of ossification begin to grow (hypertrophy).
- Then calcification of the matrix occurs and the hypertrophic chondrocytes begin to die.
- The hypertrophic chondrocytes (before apoptosis) secrete Vascular Endothelial Cell Growth Factor that induces the sprouting of blood vessels from the perichondrium.
- Blood vessels forming the periosteal bud invade the cavity left by the chondrocytes and branch in opposite directions along the length of the shaft.
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- For one, the primary cell types are chondrocytes as opposed to osteocytes.
- Chondrocytes are first chondroblast cells that produce the collagen extracellular matrix (ECM) and then get caught in the matrix.
- They lie in spaces called lacunae with up to eight chondrocytes located in each.
- Chondrocytes rely on diffusion to obtain nutrients as, unlike bone, cartilage is avascular, meaning there are no vessels to carry blood to cartilage tissue.
- Chondrocytes lie between the fibers.
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- Quiescent chondrocytes are found here.
- Zone of cell proliferation: Closer to the marrow cavity, chondrocytes in this region multiply and arrange themselves into longitudinal columns of flattened lacunae.
- Zone of bone deposition (ossification): The walls between the lacunae break down and the chondrocytes die.
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- In puberty, increasing levels of estrogen, in both females and males, leads to increased apoptosis of chondrocytes in the epiphyseal plate.
- Depletion of chondrocytes due to apoptosis leads to less ossification, and growth slows down and later stops when the cartilage has been completely replaced by bone.
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- Chondrocytes in the primary center of ossification begin to grow (hypertrophy).
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- Articular cartilage is maintained by embedded chondrocytes that comprise only 1% of the cartilage volume, and remodeling of cartilage is predominantly affected by changes and rearrangements of the collagen matrix, which responds to tensile and compressive forces experienced by the cartilage.
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- For example, certain cells respond to changes in oxygen tension as part of their normal development, such as chondrocytes, which must adapt to low oxygen conditions or hypoxia during skeletal development.