antagonism

(noun)

When a substance binds to the same site an agonist would bind to without causing activation of the receptor.

Related Terms

  • permissiveness
  • synergism

Examples of antagonism in the following topics:

  • Blocking of Hormone Receptors

    • It narrows the definition of antagonism to consider only those compounds with opposing activities at a single receptor.
    • The term "non-competitive antagonism" (sometimes called non-surmountable antagonists) can be used to describe two distinct phenomena: one in which the antagonist binds to the active site of the receptor, and one in which the antagonist binds to an allosteric site of the receptor.
    • While the mechanism of antagonism is different in both of these phenomena, they are both called "non-competitive" because the end-results of each are functionally very similar.
    • This type of antagonism produces a kinetic profile in which "the same amount of antagonist blocks higher concentrations of agonist better than lower concentrations of agonist. "
  • Interactions of Hormones at Target Cells

    • Differentiate among the interactions (permissiveness, antagonism, and synergy) of hormones at target cells
  • Anticoagulants

    • Coumadins such as warfarin are oral anticoagulant pharmaceuticals that antagonize the effects of vitamin K1.
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