Angiogenesis inhibitors

(noun)

A substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are a normal part of the body's control, some are administered as drugs, and some come from diet.

Related Terms

Examples of Angiogenesis inhibitors in the following topics:

  • Angiogenesis and Disease

    • It is also a fundamental step in the transition of tumors from a dormant state to a malignant one, leading to the use of angiogenesis inhibitors.
    • Bone marrow cell recruitment also participates in tumor angiogenesis .
    • Angiogenesis is also required for the spread of a tumor, or metastasis.
    • Angiogenesis becomes clearly evident during dysplasia and is critical for further growth.
    • Targeting tumor angiogenesis may be a novel strategy for preventing cancer.

  • Lung Cancer

    • The epidermal growth factor receptor (EGFR) regulates cell proliferation, apoptosis, angiogenesis, and tumor invasion.
    • Mutations and amplification of EGFR are common in non-small-cell lung cancer and provide the basis for treatment with EGFR-inhibitors.

  • Overview of Hemostasis

    • When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor, which causes platelet adherence during the initial formation of a clot.

  • Development of the Heart

    • The development of the circulatory system initially occurs by the process of vasculogenesis followed by angiogenesis, or the sprouting of new vessels from pre-existing ones .
    • Though similar to angiogenesis, the two are different in one aspect: The term angiogenesis denotes the formation of new blood vessels from pre-existing ones, whereas vasculogenesis is the term used for the formation of new blood vessels when there are no pre-existing ones.
    • For example, if a monolayer of endothelial cells begins sprouting to form capillaries, angiogenesis is occurring.
    • These vascular trees are then pruned and extended through angiogenesis.

  • Fibrinolysis

    • T-PA and urokinase are themselves inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2 (PAI-1 and PAI-2).
    • Plasmin activity is also reduced by thrombin-activatable fibrinolysis inhibitor (TAFI), which modifies fibrin to make it more resistant to the tPA-mediated plasminogen.

  • Development of Blood

    • Angiogenesis also contributes to the complexity of the initial network; endothelial buds form by an extrusion-like process which is prompted by the expression of vascular endothelial growth factor (VEGF).
    • Angiogenesis is generally responsible for colonizing individual organ systems with blood vessels, whereas vasculogenesis lays down the initial pipelines of the network.

  • Development of Blood and Blood Vessels

    • Formation of new blood vessels occurs by two different processes: vasculogenesis and angiogenesis.

  • Basement Membranes and Diseases

    • The basement membrane is also essential for angiogenesis (development of new blood vessels).

  • Platelets

    • They also release wound healing-associated growth factors including platelet-derived growth factor (PDGF), which directs cell movement; TGF beta, which stimulates the deposition of extracellular matrix tissue into a wound during healing; and vascular endothelial growth factor (VEGF), which stimulates angiogenesis, or the regrowth of blood vessels.

  • Platelet Plug Formation

    • PDGF and VEGF are involved in angiogenesis, the growth of new blood vessels and cell cycle proliferation (division) following injury.