Structure of GD2
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastomas and melanomas, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. The relatively tumor-specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T-cell receptors.
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