somatostatin

(noun)

A polypeptide hormone, secreted by the pancreas, that inhibits the production of certain other hormones.

Related Terms

Examples of somatostatin in the following topics:

  • Types of Cells in the Pancreas

    • It is an endocrine gland that produces several important hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide.
    • Delta cells that produce somatostatin, and make up 3–10% of the total islet cells.
    • Somatostatin is a hormone that suppresses the release of the other hormones made in the pancreas.

  • Overview of Pancreatic Islets

    • Delta cells that produce somatostatin and make up 3–10% of the total islet cells.
    • Somatostatin is a hormone that suppresses the release of the other hormones made in the pancreas.
    • Somatostatin inhibits the activity of alpha cells and beta cells.

  • Histology of the Pancreas

    • It is both an endocrine gland producing several important hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide, as well as a digestive organ, secreting pancreatic juice containing digestive enzymes that assist the absorption of nutrients and the digestion in the small intestine.
    • They are relatively difficult to distinguish using standard staining techniques, but they can be classified by their secretion: α cells secrete glucagon (increase glucose in blood), β cells secrete insulin (decrease glucose in blood), delta cells secrete somatostatin (regulates/stops α and β cells), and PP cells or gamma cells, secrete pancreatic polypeptide.

  • Pancreas

    • As an endocrine gland, the pancreas produces several important hormones which include insulin, glucagon, somatostatin and pancreatic polypeptide.
    • They are relatively difficult to distinguish using standard staining techniques, but they can be classified by their secretion: α cells secrete glucagon (increase glucose in blood), β cells secrete insulin (decrease glucose in blood), delta cells secrete somatostatin (regulates/stops α and β cells), and PP cells or gamma cells, secrete pancreatic polypeptide.

  • Pancreatic Juice

    • It is both an endocrine gland producing several important hormones including insulin, glucagon, somatostatin, and pancreatic polypeptide, and a digestive organ, secreting pancreatic juice containing digestive enzymes that assist the absorption of nutrients and the digestion in the small intestine.

  • Hormonal Responses to Food

    • However, when the stomach is emptied, the acidic environment need not be maintained and a hormone called somatostatin stops the release of hydrochloric acid.

  • Hormonal Regulation of Growth

    • GH release is stimulated by growth hormone-releasing hormone (GHRH) and is inhibited by growth hormone-inhibiting hormone (GHIH), also called somatostatin.

  • Digestive Properties of the Stomach

    • It is inhibited by a pH normally less than four (high acid), as well as the hormone somatostatin.

  • Hypothalamus

    • The hypothalamus contains thyrotropin-releasing hormone, gonadotropin-releasing hormone, growth hormone-releasing hormone, corticotropin-releasing hormone, somatostatin, and dopamine, as well as vasopressin and oxytocin.

  • Mammary Glands

    • Shrinkage of the mammary duct tree and ECM remodeling by various proteinase is under the control of somatostatin and other growth-inhibiting hormones and local factors.