proteasome

(noun)

a complex protein, found in bacterial, archaeal and eukaryotic cells, that breaks down other proteins via proteolysis

Related Terms

Examples of proteasome in the following topics:

  • Proteolytic Degradation

    • The proteasomes are a major component of a complex and highly regulated mechanism.
    • The proteasome is able to degrade proteins based on the presence of a ubiquitinprotein.
    • The lysosomal pathway, in comparison to the proteasomal pathway, is typically non-selective.
    • Schematic of the proteolytic degradation pathway that utilizes proteasomal complexes.
    • The protein is tagged with several ubiquitin signals that target the proteasome.

  • Regulating Protein Activity and Longevity

    • These proteins are moved to the proteasome, an organelle that functions to remove proteins to be degraded .
    • Proteins with ubiquitin tags are marked for degradation within the proteasome.

  • Antigen-Presenting Cells

    • The host cell digests cytoplasmic proteins by a specialized enzyme complex, the proteasome, into small peptides.

  • Major Histocompatibility Complex Antigens (Self-Antigens)

    • MHC class I pathway: proteins in the cytosol are degraded by the proteasome, liberating peptides internalized by TAP channel in the endoplasmic reticulum, there associating with MHC-I molecules freshly synthesized.