lymphoid vs. myeloid model

(noun)

This model of lymphopoiesis has the virtue of relative simplicity, agreement with nomenclature and terminology, and validity for research with mice. 

Examples of lymphoid vs. myeloid model in the following topics:

  • Development of the Immune System

    • The lymphoid vs. myeloid model of lymphopoiesis has the virtue of relative simplicity and agreement with nomenclature and terminology, as well as validity for tests with mice. pHSC pluripotent, self-renewing, hematopoietic stem cells give rise to MPP multipotent progenitors (these give rise to ELP, or PRO, prolymphocytes); early lymphoid progenitors; and finally to the CLP common lymphoid progenitor, a cell type fully committed to the lymphoid lineage. pHSC, MPP and ELP cells are not fully committed to the lymphoid lineage because if one is removed to a different location, it may differentiate into non-lymphoid progeny.
    • However, CLP are committed to the lymphoid lineage.
    • NK cells Dendritic cells (lymphoid lineage; DC2) Progenitor B cells Pro-B cells => Early Pro (or pre-pre)-B cells => Late Pro (or pre-pre)-B cells Large Pre-B cells => Small Pre-B cells Immature B cells B Cells => (B1 cells; B2 cells) Plasma cells Pro-T cells T-cells.
    • Side by side comparison of the new and old lineage models.
    • This revised flowchart indicates multi-lymphoid progenitor, early thymic progenitor, lymphoid extrusion, CD4 and CD8, monocyte/macrophate, myeloid extrusion, and T-cells.