intramembranous ossification

(noun)

Production of bone tissue during fetal development without a cartilage template. The membrane that occupies the place of the future bone resembles connective tissue and ultimately forms the periosteum, or outer bone layer.

Related Terms

  • osteon
  • trabecula
  • canaliculi
  • endochondral ossification
  • mesenchyme

(noun)

A process that occurs during fetal development to produce bone tissue without a cartilage template. The membrane that occupies the place of the future bone resembles connective tissue and ultimately forms the periosteum, or outer bone layer.

Related Terms

  • osteon
  • trabecula
  • canaliculi
  • endochondral ossification
  • mesenchyme

Examples of intramembranous ossification in the following topics:

  • Embryonic and Fetal Bone Formation

    • During fetal development, bone tissue is created through intramembranous ossification and endochondral ossification.
    • The skull and vertebral column are produced by intramembranous ossification.
    • Intramembranous ossification is one of the two essential processes during fetal development of the mammalian skeletal system.
    • Unlike the other process of bone creation— endochondral ossification—intramembranous ossification does not involve cartilage.
    • Unlike intramembranous ossification, cartilage is present during endochondral ossification.
  • Bone Development

    • Intramembranous ossification stems from fibrous membranes in flat bones, while endochondral ossification stems from long bone cartilage.
    • The development of bone from fibrous membranes is called intramembranous ossification; development from hyaline cartilage is called endochondral ossification.
    • Intramembranous ossification is the process of bone development from fibrous membranes.
    • They then differentiate into osteoblasts at the ossification center.
    • Endochondral ossification is the process of bone development from hyaline cartilage.
  • Stages of Bone Development

    • The formation of bone during the fetal stage of development occurs by two processes: intramembranous ossification and endochondral ossification.
    • Intramembranous ossification mainly occurs during the formation of the flat bones of the skull, as well as the mandible, maxilla, and clavicles.
    • The steps in intramembranous ossification are:
    • Endochondral ossification begins with points in the cartilage called "primary ossification centers."
    • They mostly appear during fetal development, though a few short bones begin their primary ossification after birth.
  • Development of the Skeleton

    • Early in gestation, a fetus has a cartilaginous skeleton that becomes bone in the gradual process of endochondral ossification.
    • Early in gestation, a fetus has a cartilaginous skeleton from which the long bones and most other bones gradually form throughout development and for years after birth in a process called endochondral ossification.
    • Intramembranous ossification is the direct laying of bone into the primitive connective tissue (mesenchyme).
    • Endochondral ossification involves cartilage as a precursor.
    • Chondrocytes in the primary center of ossification begin to grow (hypertrophy).
  • Fontanels

    • The ossification of the bones of the skull causes the fontanelles to close over a period of 18 to 24 months; they eventually form the sutures of the neurocranium.
    • This is called intramembranous ossification.
  • Growth of Bone

    • It is a layer of hyaline cartilage where ossification occurs in immature bones.
    • The newly-deposited bone tissue at the top of the zone of ossification is called the primary spongiosa.
    • The older bone at the bottom of the zone of ossification is called the secondary spongiosa.
    • At the same time, osteoblasts via intramembranous ossification, produce new bone tissue beneath the periosteum.
    • The bottom-most row is the zone of ossification which is part of the metaphysis.
  • Postnatal Bone Growth

    • Secondary ossification occurs after birth at the epiphyses of long bones and continues until skeletal maturity.
    • Secondary ossification occurs after birth.
    • During postnatal bone formation, endochondral ossification initiates bone deposition by first generating a structural framework at the ends of long bones, within which the osteoblasts can synthesize a new bone matrix.
    • Zone of bone deposition (ossification): The walls between the lacunae break down and the chondrocytes die.
    • Differentiate among the zones of development from cartilage to bone in postnatal ossification
  • Sutures

    • As such, the degree of ossification can be a useful tool in determining age postmortem.
  • Fibrous Joints

    • Except for the mandible, all are joined together by sutures, semi-rigid articulations formed by bony ossification.
  • Cartilaginous Joints: Synchodroses

    • Depletion of chondrocytes due to apoptosis leads to less ossification, and growth slows down and later stops when the cartilage has been completely replaced by bone.
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