Examples of autoimmune in the following topics:
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- Autoimmune diseases are very often treated with steroids.
- Autoimmunity should not be confused with alloimmunity.
- While a high level of autoimmunity is unhealthy, a low level of autoimmunity may actually be beneficial.
- A person's sex also seems to have some role in the development of autoimmunity, classifying most autoimmune diseases as sex-related diseases.
- Define autoimmunity and explain how it gives rise to autoimmune disease
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- Autoimmune diseases are very often treated with steroids.
- Autoimmunity should not be confused with alloimmunity.
- A person's sex also seems to have some role in the development of autoimmunity, classifying most autoimmune diseases as sex-related diseases.
- According to the American Autoimmune Related Diseases Association (AARDA), autoimmune diseases that develop in men tend to be more severe.
- The reasons for the sex role in autoimmunity are unclear.
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- Autoimmune diseases are an inappropriate immune response against tissues in the body.
- Autoimmune diseases are commonly considered complex immune disorders.
- This has led to a "common cause hypothesis" of autoimmune disorders.
- However, defects of one or more of these genes do not cause an autoimmune disease, but only predispose a person for an autoimmune disease.
- The factors that trigger an autoimmune disease are still unknown.
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- In autoimmune heart diseases, the body's immune defense system mistakes its own cardiac antigens as foreign, and attacks them.
- Autoimmune heart diseases result when the body's own immune defense system mistakes cardiac antigens as foreign, and attacks them, leading to inflammation of the heart as a whole, or in parts.
- The most common form of autoimmune heart disease is rheumatic heart disease, or rheumatic fever.
- A typical mechanism of autoimmunity is autoantibodies, or auto-toxic T-lymphocyte mediated tissue destruction.
- Aetiologically, autoimmune heart disease is most commonly seen in children with a history of sore throat caused by a streptococcal infection.
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- The types of hypersensitivities include immediate, delayed, and autoimmunity hypersensitivities.
- Most types of autoimmunity involve the humoral immune response.
- Autoimmunity can develop with time; its causes may be rooted in molecular mimicry.
- These antibodies can damage heart muscle with autoimmune attacks, leading to rheumatic fever.
- Distinguish between the disruptions to the immune system caused by allergies and autoimmunity
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- Cell-mediated autoimmunity can happen by several mechanisms involving cells of the immune system and their receptors.
- Several mechanisms are thought to be operative in the pathogenesis of autoimmune diseases, against a backdrop of genetic predisposition and environmental modulation.
- When tolerance to self proteins is lost, DQ may become involved in autoimmune disease.
- Two autoimmune diseases in which HLA-DQ is involved are celiac disease and diabetes mellitus type 1.
- Define cell-mediated autoimmunity and describe the mechanisms that are thought to operate in the pathogenesis of autoimmune disease
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- One subtype is called idiopathic or unknown cause of adrenal insufficiency. 80% are due to an autoimmune disease called Addison's disease or autoimmune adrenalitis.
- For chronic adrenal insufficiency, the major contributors are autoimmune adrenalitis, tuberculosis, AIDS, and metastatic disease.
- Autoimmune adrenalitis may be part of Type 2 autoimmune polyglandular syndrome, (which can include type 1 diabetes), hyperthyroidism, autoimmune thyroid disease (also known as autoimmune thyroiditis and Hashimoto's disease).
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- Systemic lupus erythematosus (SLE) is an autoimmune disease that can occur in any organ or tissue in the body.
- Systemic lupus erythematosus, often abbreviated to SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body.
- As with other autoimmune diseases, the immune system attacks the body's own cells and tissue, resulting in inflammation and tissue damage.
- It is the prototypical autoimmune disease.
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- A hypersensitivity reaction refers to an overreactive immune system triggered by allergies and autoimmunity.
- Hypersensitivity (also called hypersensitivity reaction) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity, and are commonly mediated by antibodies.
- Associated disorders: Autoimmune hemolytic anemia, thrombocytopenia, Erythroblastosis, fetalis, Goodpasture's syndrome, Membranous nephropathy, Graves' disease, Myasthenia Gravis.
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- This process does not remove thymocytes that may become sensitized against self-antigens, which causes autoimmunity.
- The potentially autoimmune cells are removed by the process of negative selection.
- Autoimmune diseases reflect a loss of central tolerance, in which the body's own B and T cells become sensitized towards self antigens.
- Many autoimmune disorders are humoral in that they are primarily antibody mediated, but many disorders are T cell mediated instead, such as Chrohn's disease (a disease in which T cells attack the colon).
- These autoimmune disorders may be due to problems in negative selection, and tend to have genetic components as well.