autoantibody

(noun)

an antibody formed in response to an agent (autoantigen) produced by the organism itself

Related Terms

  • histamine

Examples of autoantibody in the following topics:

  • Type 1 Diabetes Mellitus

    • Still, a process that appears to be common to most risk factors is an autoimmune response towards beta cells, involving an expansion of autoreactive CD4+ and CD8+ T helper cells, autoantibody-producing B cells, and activation of the innate immune system.
    • The appearance of diabetes-related autoantibodies has been shown to be able to predict the appearance of diabetes type 1 before any hyperglycemia arises.
    • By definition, its diagnosis can be made first at the appearance of clinical symptoms and/or signs, but the emergence of autoantibodies may itself be termed "latent autoimmune diabetes".
  • The Complement System and Heart Disease

    • A typical mechanism of autoimmunity is autoantibodies, or auto-toxic T-lymphocyte mediated tissue destruction.
  • Fluorescent Antibodies

    • This technique is used extensively for the detection of autoantibodies and antibodies to tissue and cellular antigens.
  • Hypersensitivities

    • Antibodies that inappropriately mark self components as foreign are termed autoantibodies.
    • In systemic lupus erythematosus, a diffuse autoantibody response to the individual's own DNA and proteins results in various systemic diseases.
  • Type II (Cytotoxic) Reactions

    • This is caused by thyroid autoantibodies that activate the Thyroid Stimulating Hormone receptor, thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter).
  • Medical Uses of Hematopoietic Growth Factors

    • Trials of a modified recombinant form, megakaryocyte growth and differentiation factor (MGDF), were stopped when healthy volunteers developed autoantibodies to endogenous thrombopoietin and then developed thrombocytopenia themselves.
  • Cell-Mediated Autoimmune Reactions

    • More indirect aberrant activation of B cells can also be envisaged with autoantibodies to acetyl choline receptor (on thymic myoid cells) and hormone binding proteins.
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