autoantibody

Examples of autoantibody in the following topics:

• Type 1 Diabetes Mellitus

  • Still, a process that appears to be common to most risk factors is an autoimmune response towards beta cells, involving an expansion of autoreactive CD4+ and CD8+ T helper cells, autoantibody-producing B cells, and activation of the innate immune system.
  • The appearance of diabetes-related autoantibodies has been shown to be able to predict the appearance of diabetes type 1 before any hyperglycemia arises.
  • By definition, its diagnosis can be made first at the appearance of clinical symptoms and/or signs, but the emergence of autoantibodies may itself be termed "latent autoimmune diabetes".

• The Complement System and Heart Disease

  • A typical mechanism of autoimmunity is autoantibodies, or auto-toxic T-lymphocyte mediated tissue destruction.

• Fluorescent Antibodies

  • This technique is used extensively for the detection of autoantibodies and antibodies to tissue and cellular antigens.

• Hypersensitivities

  • Antibodies that inappropriately mark self components as foreign are termed autoantibodies.
  • In systemic lupus erythematosus, a diffuse autoantibody response to the individual's own DNA and proteins results in various systemic diseases.

• Type II (Cytotoxic) Reactions

  • This is caused by thyroid autoantibodies that activate the Thyroid Stimulating Hormone receptor, thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter).

• Medical Uses of Hematopoietic Growth Factors

  • Trials of a modified recombinant form, megakaryocyte growth and differentiation factor (MGDF), were stopped when healthy volunteers developed autoantibodies to endogenous thrombopoietin and then developed thrombocytopenia themselves.

• Cell-Mediated Autoimmune Reactions

  • More indirect aberrant activation of B cells can also be envisaged with autoantibodies to acetyl choline receptor (on thymic myoid cells) and hormone binding proteins.