anticodon

(noun)

a sequence of three nucleotides in transfer RNA that binds to the complementary triplet (codon) in messenger RNA, specifying an amino acid during protein synthesis

Related Terms

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Examples of anticodon in the following topics:

  • Processing of tRNAs and rRNAs

    • Mature tRNAs take on a three-dimensional structure through intramolecular basepairing to position the amino acid binding site at one end and the anticodon in an unbasepaired loop of nucleotides at the other end.
    • The anticodon is a three-nucleotide sequence, unique to each different tRNA, that interacts with a messenger RNA (mRNA) codon through complementary base pairing.
    • The cognate amino acid for a tRNA is the one specified by its anticodon.
    • The anticodon nucleotides are shown in a lighter shade of red.
    • The anticodon AAG binds the codon UUC on the mRNA.
  • The Protein Synthesis Machinery

    • This is called the tRNA's anticodon.
    • Each different tRNA has a different anticodon.
    • The tRNA with this anticodon would be linked to the amino acid leucine.
    • (the amino acid specified by its anticodon is a tRNA's cognate amino acid.)
    • The opposite end of the folded tRNA has the anticodon loop where the tRNA will basepair to the mRNA codon.
  • The Mechanism of Protein Synthesis

    • The aminoacyl-tRNA with an anticodon complementary to the A site codon lands in the A site.
    • In the E site, the uncharged tRNA detaches from its anticodon and is expelled .
    • A new aminoacyl-tRNA with an anticodon complementary to the new A-site codon enters the ribosome at the A site and the elongation process repeats itself.
    • There are no tRNAs with anticodons complementary to stop codons, so no tRNAs enter the A site.
    • During translation elongation, the incoming aminoacyl-tRNA enters the ribosome A site, where it binds if the tRNA anticodon is complementary to the A site mRNA codon.
  • The Initiation Complex and Translation Rate

    • The anticodon on the tRNAi then binds to the start codon via basepairing.
    • The anticodon on tRNAi-Met basepairs with the AUG codon.
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