antagonism

(noun)

When a substance binds to the same site an agonist would bind to without causing activation of the receptor.

Related Terms

  • permissiveness
  • synergism

Examples of antagonism in the following topics:

  • Blocking of Hormone Receptors

    • It narrows the definition of antagonism to consider only those compounds with opposing activities at a single receptor.
    • The term "non-competitive antagonism" (sometimes called non-surmountable antagonists) can be used to describe two distinct phenomena: one in which the antagonist binds to the active site of the receptor, and one in which the antagonist binds to an allosteric site of the receptor.
    • While the mechanism of antagonism is different in both of these phenomena, they are both called "non-competitive" because the end-results of each are functionally very similar.
    • This type of antagonism produces a kinetic profile in which "the same amount of antagonist blocks higher concentrations of agonist better than lower concentrations of agonist. "
  • Interactions of Hormones at Target Cells

    • Differentiate among the interactions (permissiveness, antagonism, and synergy) of hormones at target cells
  • A World War

    • The war was driven by the antagonism between Great Britain and the Bourbons in France and Spain, caused by overlapping interests in their colonial and trade empires and the antagonism between the Hohenzollerns in Prussia, the Habsburgs of the Holy Roman Emperors, and the archdukes in Austria resulting from territorial and hegemonic conflicts in the Holy Roman Empire.
  • The Labor Movement's Early Years

    • Another factor that helped reduce class antagonism is the fact that U.S. workers -- at least white male workers -- were granted the right to vote sooner than workers in other countries.
  • The Marxist Critique of Capitalism

    • Normative Marxism advocates for a revolutionary overthrow of capitalism that would lead to socialism, before eventually transforming into communism after class antagonisms and the state cease to exist.
  • Antibiotic Discovery

    • Louis Pasteur observed, "if we could intervene in the antagonism observed between some bacteria, it would offer perhaps the greatest hopes for therapeutics".
  • Liberty

    • As such, he describes an inherent and continuous antagonism between liberty and authority.
  • Theories of Democracy

    • Democracy's role is to make visible and challenge those relations by allowing for difference, dissent, and antagonisms in the decision making processes.
  • Anticoagulants

    • Coumadins such as warfarin are oral anticoagulant pharmaceuticals that antagonize the effects of vitamin K1.
  • The Conflict Perspective

    • Sociologists in the tradition of conflict theory argue that the economic and political structures of a society create social divisions, classes, hierarchies, antagonisms and conflicts that produce and reproduce inequalities.
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