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RNA Processing in Eukaryotes
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Concept Version 9
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mRNA Processing

Poly (A) Polymerase adds a 3' poly (A) tail to the pre-mRNA.

Poly (A) Polymerase adds a 3' poly (A) tail to the pre-mRNA.

The pre-mRNA is cleaved off the rest of the growing transcript before RNA Polymerase II has stopped transcribing. This cleavage is done by an endonuclease-containing protein complex that binds to an AAUAAA sequence upstream of the cleavage site and to a GU-rich sequence downstream of the cut site. Immediately after the cleavage, Poly (A) Polymerase (PAP), which is also part of the protein complex, catalyzes the addition of up to 200 A nucleotides to the 3' end of the just-cleaved pre-mRNA.

Source

    Boundless vets and curates high-quality, openly licensed content from around the Internet. This particular resource used the following sources:

    "Original figure by Ross Whitwam. Licensed CC BY-SA 4.0."
    Ross Whitwam CC BY-SA 3.0.

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