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Boundless Biology
Genes and Proteins
Eukaryotic Transcription
Biology Textbooks Boundless Biology Genes and Proteins Eukaryotic Transcription
Biology Textbooks Boundless Biology Genes and Proteins
Biology Textbooks Boundless Biology
Biology Textbooks
Biology
Concept Version 12
Created by Boundless

Elongation and Termination in Eukaryotes

The FACT protein dimer allows RNA Polymerase II to transcribe through packaged DNA

The FACT protein dimer allows RNA Polymerase II to transcribe through packaged DNA

DNA in eukaryotes is packaged in nucleosomes, which consist of an octomer of 4 different histone proteins. When DNA is tightly wound twice around a nucleosome, RNA Polymerase II cannot access it for transcription. FACT removes two of the histones from the nucleosome immediately ahead of RNA Polymerase, loosening the packaging so that RNA Polymerase II can continue transcription. FACT also reassembles the nucleosome immediately behindd the RNA Polymerase by returning the missing histones.

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    "Original%20figure%20by%20Ross%20Whitwam.%20Licensed%20CC%20BY-SA%204.0."
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Related Terms

  • nucleosome
  • histone
  • chromatin
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