troponin

(noun)

a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle, or any member of this complex

Related Terms

  • ATPase
  • M-line

Examples of troponin in the following topics:

  • Regulatory Proteins

    • Tropomyosin and troponin prevent myosin from binding to actin while the muscle is in a resting state.
    • The protein complex troponin binds to tropomyosin, helping to position it on the actin molecule.
    • If present, calcium ions bind to troponin, causing conformational changes in troponin that allow tropomyosin to move away from the myosin-binding sites on actin.
    • Calcium then binds to troponin, causing the troponin to change shape and remove the tropomyosin from the binding sites.
    • Describe how calcium, tropomyosin, and the troponin complex regulate the binding of actin by myosin
  • ATP and Muscle Contraction

    • The muscle contraction cycle is triggered by calcium ions binding to the protein complex troponin, exposing the active-binding sites on the actin.
  • Excitation–Contraction Coupling

    • The action potential triggers the sarcoplasmic reticulum to release of Ca2+, which activate troponin and stimulate muscle contraction.
  • Skeletal Muscle Fibers

    • Thin filaments are composed of actin, tropomyosin, and troponin.
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