free radical

(noun)

Any molecule, ion or atom that has one or more unpaired electrons; they are generally highly reactive and often only occur as transient species.

Related Terms

  • enzyme

Examples of free radical in the following topics:

  • Peroxisomes

    • Reactive oxygen species (ROS), such as peroxides and free radicals, are the highly-reactive products of many normal cellular processes, including the mitochondrial reactions that produce ATP and oxygen metabolism.
    • Examples of ROS include the hydroxyl radical OH, H2O2, and superoxide (O−2).
    • Free radicals are reactive because they contain free unpaired electrons; they can easily oxidize other molecules throughout the cell, causing cellular damage and even cell death.
    • Free radicals are thought to play a role in many destructive processes in the body, from cancer to coronary artery disease.
    • Peroxisomes oversee reactions that neutralize free radicals.
  • Pineal Gland and Gonads

    • Melatonin is an effective antioxidant, protecting the CNS from free radicals such as nitric oxide and hydrogen peroxide.
  • Free Energy

    • Free energy, called Gibbs free energy (G), is usable energy or energy that is available to do work.
    • A measurement of free energy is used to quantitate these energy transfers.
    • Free energy is called Gibbs free energy (G) after Josiah Willard Gibbs, the scientist who developed the measurement.
    • A negative ∆G also means that the products of the reaction have less free energy than the reactants because they gave off some free energy during the reaction.
    • In this case, the products have more free energy than the reactants.
  • Varying Rates of Speciation

    • Under some conditions, selection occurs quickly or radically.
  • ATP: Adenosine Triphosphate

    • Since ATP hydrolysis releases energy, ATP synthesis must require an input of free energy.
    • Exactly how much free energy (∆G) is released with the hydrolysis of ATP, and how is that free energy used to do cellular work?
    • Unless quickly used to perform work, ATP spontaneously dissociates into ADP + Pi, and the free energy released during this process is lost as heat.
    • The Na+/K+ pump gains the free energy and undergoes a conformational change, allowing it to release three Na+ to the outside of the cell.
    • By donating free energy to the Na+/K+ pump, phosphorylation drives the endergonic reaction.
  • Biodiversity Change through Geological Time

    • This hypothesis, proposed first in 1980, was a radical explanation based on a sharp spike in the levels of iridium (which rains down from space in meteors at a fairly constant rate, but is otherwise absent on earth's surface) at the rock stratum that marks the boundary between the Cretaceous and Paleogene periods .
    • It was a radical explanation, but the report of an appropriately aged and sized impact crater in 1991 made the hypothesis more credible.
  • Class Scyphozoa

    • Scyphozoans are free-swimming, polymorphic, dioecious, and carnivorous cnidarians with a prominent medusa morphology.
    • Scyphozoans live most of their life cycle as free-swimming, solitary carnivores.
  • The Evolution of Mitochondria

    • Mitochondria are energy-producing organelles that are thought to have once been a type of free-living alpha-proteobacterium.
    • As the amount of oxygen increased in the atmosphere billions of years ago and as successful aerobic prokaryotes evolved, evidence suggests that an ancestral cell with some membrane compartmentalization engulfed a free-living aerobic prokaryote, specifically an alpha-proteobacterium, thereby giving the host cell the ability to use oxygen to release energy stored in nutrients.
    • Alpha-proteobacteria are a large group of bacteria that includes species symbiotic with plants, disease organisms that can infect humans via ticks, and many free-living species that use light for energy.
    • These features all support that mitochondria were once free-living prokaryotes.
  • Symbiosis between Bacteria and Eukaryotes

    • In soil, members of the genus Clostridium are examples of free-living, nitrogen-fixing bacteria.
    • Symbionts may fix more nitrogen in soils than free-living organisms by a factor of 10.
    • Nitrogenase, the enzyme that fixes nitrogen, is inactivated by oxygen, so the nodule provides an oxygen-free area for nitrogen fixation to take place.
  • ATP and Muscle Contraction

    • ATP is critical for muscle contractions because it breaks the myosin-actin cross-bridge, freeing the myosin for the next contraction.
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