endergonic reaction

Examples of endergonic reaction in the following topics:

• Free Energy

  • These chemical reactions are called endergonic reactions; they are non-spontaneous.
  • An endergonic reaction will not take place on its own without the addition of free energy.
  • Therefore, the chemical reactions involved in anabolic processes are endergonic reactions.
  • Exergonic and endergonic reactions result in changes in Gibbs free energy.
  • Exergonic reactions release energy; endergonic reactions require energy to proceed.

• ATP: Adenosine Triphosphate

  • Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions to harness the energy within the bonds of ATP.
  • ATP provides the energy for both energy-consuming endergonic reactions and energy-releasing exergonic reactions, which require a small input of activation energy.
  • Cells couple the exergonic reaction of ATP hydrolysis with the endergonic reactions of cellular processes.
  • By donating free energy to the Na+/K+ pump, phosphorylation drives the endergonic reaction.
  • In this example, the exergonic reaction of ATP hydrolysis is coupled with the endergonic reaction of converting glucose for use in the metabolic pathway.

• Activation Energy

  • Activation energy must be considered when analyzing both endergonic and exergonic reactions.
  • Cells will at times couple an exergonic reaction $(\Delta G<0)$ with endergonic reactions $(\Delta G>0)$, allowing them to proceed.
  • The free energy released from the exergonic reaction is absorbed by the endergonic reaction.
  • Although the image above discusses the concept of activation energy within the context of the exergonic forward reaction, the same principles apply to the reverse reaction, which must be endergonic.
  • In this endergonic reaction, activation energy is still required to transform the reactants A + B into the product C.

• ATP in Metabolism

  • In this way, ATP is a direct link between the limited set of exergonic pathways of glucose catabolism and the multitude of endergonic pathways that power living cells.
  • The energy from ATP can also be used to drive chemical reactions by coupling ATP hydrolysis with another reaction process in an enzyme.
  • During an endergonic chemical reaction, ATP forms an intermediate complex with the substrate and enzyme in the reaction.
  • This is illustrated by the following generic reaction:
  • In phosphorylation reactions, the gamma phosphate of ATP is attached to a protein.

• The Two Parts of Photosynthesis

  • Light-dependent and light-independent reactions are two successive reactions that occur during photosynthesis.
  • Just as the name implies, light-dependent reactions require sunlight.
  • Photosystems consist of a light-harvesting complex and a reaction center.
  • In the light-independent reactions or Calvin cycle, the energized electrons from the light-dependent reactions provide the energy to form carbohydrates from carbon dioxide molecules.
  • Photosynthesis takes place in two stages: light-dependent reactions and the Calvin cycle (light-independent reactions).

• Hydrolysis

  • During these reactions, the polymer is broken into two components.
  • These reactions are in contrast to dehydration synthesis (also known as condensation) reactions.
  • Dehydration and hydrolysis reactions are chemical reactions that are catalyzed, or "sped up," by specific enzymes; dehydration reactions involve the formation of new bonds, requiring energy, while hydrolysis reactions break bonds and release energy.
  • This is the reverse of the dehydration synthesis reaction joining these two monomers.
  • This is the reverse of the dehydration synthesis reaction joining these two monomers.

• Enzyme Active Site and Substrate Specificity

  • In some reactions, a single-reactant substrate is broken down into multiple products.
  • Two reactants might also enter a reaction, both become modified, and leave the reaction as two products.
  • This dynamic binding maximizes the enzyme's ability to catalyze its reaction.
  • The enzyme will always return to its original state at the completion of the reaction.
  • After an enzyme is done catalyzing a reaction, it releases its products (substrates).

• Chemical Reactions and Molecules

  • The equations that describe these reactions contain a unidirectional arrow and are irreversible.
  • Reversible reactions are those that can go in either direction.
  • In biological reactions, however, equilibrium is rarely obtained because the concentrations of the reactants or products or both are constantly changing, often with a product of one reaction being a reactant for another.
  • These reactions are important for maintaining the homeostasis of our blood.
  • Explore reactions in which chemical bonds are formed and broken with this model.

• Control of Metabolism Through Enzyme Regulation

  • A cell's function is encapsulated by the chemical reactions it can carry out.
  • Enzymes lower the activation energies of chemical reactions; in cells, they promote those reactions that are specific to the cell's function.
  • This prevents the enzyme from lowering the activation energy of the reaction, and the reaction rate is reduced.
  • Allosteric activators can increase reaction rates.
  • This increases the reaction rate.

• Regulatory Mechanisms for Cellular Respiration

  • Some reactions are controlled by having two different enzymes: one each for the two directions of a reversible reaction.
  • Reactions that are catalyzed by only one enzyme can go to equilibrium, stalling the reaction.
  • In contrast, if two different enzymes (each specific for a given direction) are necessary for a reversible reaction, the opportunity to control the rate of the reaction increases and equilibrium is not reached.
  • A number of enzymes involved in each of the pathways (in particular, the enzyme catalyzing the first committed reaction of the pathway) are controlled by attachment of a molecule to an allosteric (non-active) site on the protein.
  • This alteration of the protein's (the enzyme's) structure either increases or decreases its affinity for its substrate, with the effect of increasing or decreasing the rate of the reaction.