Examples of dopamine in the following topics:
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- Treatment for the disease usually requires anti-psychotic medications that work by blocking dopamine receptors and decreasing dopamine neurotransmission in the brain.
- This decrease in dopamine can cause Parkinson's disease-like symptoms in some patients.
- For example, dopamine may also be decreased in depressed patients, or it may actually be an increase in norepinephrine and serotonin that causes the disease, and antidepressants force a feedback loop that decreases this release.
- For example, monoamine oxidase inhibitors (MAO inhibitors) block the enzyme that degrades many neurotransmitters (including dopamine, serotonin, norepinephrine), resulting in increased neurotransmitter in the synaptic cleft.
- Other types of drugs, such as norepinephrine-dopamine reuptake inhibitors and norepinephrine-serotonin reuptake inhibitors, are also used to treat depression.
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- It is the hormone and neurotransmitter most responsible for vigilant concentration in contrast to its most-chemically-similar hormone, dopamine, which is most responsible for cognitive alertness.
- Norepinephrine is synthesized from dopamine by dopamine β-hydroxylase in the secretory granules of the medullary chromaffin cells and is released from the adrenal medulla into the blood as a hormone.
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- Parkinson's disease causes the loss of dopamine neurons in the substantia nigra, a midbrain structure that regulates movement.
- One of the most-commonly prescribed drugs for Parkinson's is L-DOPA, which is a chemical that is converted into dopamine by neurons in the brain.
- This conversion increases the overall level of dopamine neurotransmission and can help compensate for the loss of dopaminergic neurons in the substantia nigra.
- Other drugs work by inhibiting the enzyme that breaks down dopamine.
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- Prolactin levels are regulated by the hypothalamic hormones, prolactin-releasing hormone (PRH) and prolactin-inhibiting hormone (PIH) (which is now known to be dopamine).