dominant lethal

(adjective)

an inheritance pattern is one in which an allele is lethal both in the homozygote and the heterozygote; this allele can only be transmitted if the lethality phenotype occurs after reproductive age

Related Terms

  • mutation
  • recessive lethal

Examples of dominant lethal in the following topics:

  • Lethal Inheritance Patterns

    • In other instances, the recessive lethal allele might also exhibit a dominant (but not lethal) phenotype in the heterozygote.
    • The dominant lethal inheritance pattern is one in which an allele is lethal both in the homozygote and the heterozygote; this allele can only be transmitted if the lethality phenotype occurs after reproductive age.
    • Individuals with mutations that result in dominant lethal alleles fail to survive even in the heterozygote form.
    • Dominant lethal alleles are very rare because, as you might expect, the allele only lasts one generation and is not transmitted.
    • However, just as the recessive lethal allele might not immediately manifest the phenotype of death, dominant lethal alleles also might not be expressed until adulthood.
  • Plant Defenses Against Pathogens

    • Many metabolites are toxic and can even be lethal to animals that ingest them.
  • Mendel's Law of Dominance

    • Rather than both alleles contributing to a phenotype, the dominant allele will be expressed exclusively.
    • It is sometimes convenient to talk about the trait corresponding to the dominant allele as the dominant trait and the trait corresponding to the hidden allele as the recessive trait.
    • For example, to say that "green peas" dominate "yellow peas" confuses inherited genotypes and expressed phenotypes.
    • Dominance is not inherent.
    • One allele can be dominant to a second allele, recessive to a third allele, and codominant to a fourth.
  • Alternatives to Dominance and Recessiveness

    • The variant may be recessive or dominant to the wild-type allele.
    • In cases of multiple alleles, dominance hierarchies can exist.
    • In this case, the wild-type allele is dominant over all the others, chinchilla is incompletely dominant over Himalayan and albino, and Himalayan is dominant over albino.
    • These pink flowers of a heterozygote snapdragon result from incomplete dominance.
    • Discuss incomplete dominance, codominance, and multiple alleles as alternatives to dominance and recessiveness
  • Excitation–Contraction Coupling

    • A lethal exposure to Sarin can cause death within one minute.
  • Genetic Variation

    • This low genetic diversity means they are often susceptible to disease and often pass on lethal recessive mutations; only about 5% of cheetahs survive to adulthood.
  • Plant Defenses Against Herbivores

    • Many metabolites are toxic and can even be lethal to animals that ingest them.
  • Disorders in Chromosome Number

    • Monosomy for autosomes is usually lethal in humans and other animals.
  • Life Cycles of Sexually Reproducing Organisms

    • The main categories of sexual life cycles in eukaryotic organisms are: diploid-dominant, haploid-dominant, and alternation of generations.
    • There are three main categories of life cycles in eukaryotic organisms: diploid-dominant, haploid-dominant, and alternation of generations.
    • Within haploid-dominant life cycles, the multicellular haploid stage is the most obvious life stage.
    • The third life-cycle type, employed by some algae and all plants, is a blend of the haploid-dominant and diploid-dominant extremes.
    • Fungi, such as black bread mold (Rhizopus nigricans), have haploid-dominant life cycles.
  • The Punnett Square Approach for a Monohybrid Cross

    • The dominant seed color is yellow; therefore, the parental genotypes were YY (homozygous dominant) for the plants with yellow seeds and yy (homozygous recessive) for the plants with green seeds, respectively.
    • If the pattern of inheritance (dominant or recessive) is known, the phenotypic ratios can be inferred as well.
    • In a test cross, the dominant-expressing organism is crossed with an organism that is homozygous recessive for the same characteristic.
    • If the dominant-expressing organism is a homozygote, then all F1 offspring will be heterozygotes expressing the dominant trait.
    • A test cross can be performed to determine whether an organism expressing a dominant trait is a homozygote or a heterozygote.
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